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Duodart (Dutasteride)
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Dutasteride

Duodart is an aza-steroid that is inasteride in which the tert-butyl group is replaced by a 2,5-bis(trifluoromethyl)phenyl group. A synthetic 4-azasteroid, Duodart is a selective inhibitor of both the type 1 and type 2 isoforms of steroid 5alpha-reductase, an intracellular enzyme that converts testosterone to 5alpha-dihydrotestosterone. Duodart is used for the treatment of symptomatic benign prostatic hyperplasia in men with an enlarged prostate gland. It has a role as an EC 1.3.1.22 [3-oxo-5alpha-steroid 4-dehydrogenase (NADP(+))] inhibitor and an antihyperplasia drug. It is an aza-steroid, a member of (trifluoromethyl)benzenes and a delta-lactam. It derives from a hydride of a 5alpha-androstane.

Other names for this medication:
Dutasteride, Deetor, Duodart, Duprost, Dutagen, Dutas, Dutasterida, Dute, Veltride,

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This study comprised consecutive myopic patients with a preoperative refractive cylinder of 0.75 D or less and a preoperative subjective sphere between -2.75 D and -11.50 D. A 68-year-old patient presented with an 8-month history of severe right-sided sciatica. The subscales may be of value for identifying problems in continuity of care and for evaluating interventions aimed at improving continuity of care for patients after hospital discharge. From the surfaces, principal axes of rotation were defined by calculating orthonormal bases of the surface vertices. Seasonal dynamics of the specific activity of radionuclides in water and in bottom deposits has been investigated.

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Little is known about the regulation and role of early neural cell death. The aim of this study was to compare both approaches with regard to IDH. Metal capture experiments were carried out in an atmospheric fluidized bed incinerator to investigate the effect of sulfur and chlorine on metal capture efficiency and the potential for simultaneous capture of metal, sulfur and chlorine by sorbents. The association of HTLV-1 and tropical spastic paraparesis in an African woman

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Deletion of the PRR in the mislocalized RcsF resulted in even higher activation of the Rcs system. Participants were also asked to record vasomotor symptoms for seven days. Enhanced uptake of In-111-bevacizumab in the liver metastases was observed in 9 of the 12 patients. Head circumference and developmental ability at the age of seven years.

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In the present study, we examined whether S100B has a similar role in the cerebellar regions, because Bergmann glia, a specialized subset of astrocytes in the cerebellar cortex, express a particularly large amount of S100B under physiologic conditions. We report a rare case of malignant paraganglioma which was asymptomatic in spite of increasing plasma levels of catecholamines. Thus these domains constitute a compact group of related enzymes, the tymo-like proteinases, within the proposed papain-like proteinase supergroup. The results suggest that intake of fermented milk products could be of value in decreasing chronic bowel discomfort following radiotherapy of pelvic malignancies.

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In addition, most conventional magnetic assembly strategies are restricted to target objects that possess magnetic properties. Effects of GABA on the expression of type I collagen gene in normal human dermal fibroblasts. To investigate potential neural mechanisms for this behavioral observation, we developed computer simulations modeling interlimb neural pathways among central pattern generators. Spatial Pattern of Attacks of the Invasive Woodwasp Sirex noctilio, at Landscape and Stand Scales.

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A 49-year-old woman with recurrent ovarian cancer clear cell carcinoma was treated by etoposide. We found that plasma from males incubating experimentally enlarged clutches exhibited significantly reduced lysis titers compared with plasma from males incubating control clutches, while this was not observed in females. Despite of exposure to CCl4 tissue levels of thiobarbituric acid (TBA) reacting substances in the liver were not increased in rats pretreated with levamisole. We could also demonstrate in frog spinal cord two distinct heavy subunits cross-reacting with either the M or the H subunit from mammals, a fact which suggests a convergent evolution for phosphorylated epitopes of neurofilaments. Tumors were observed in a real-time fashion of contrast-enhanced coded phase-inversion harmonic US after the injection of Levovist (400 mg/ml).

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Apolipoprotein E is a putative autocrine regulator of the rat ovarian theca cell compartment. Here, we will review the current and evolving agents developed for B-cell depletion or modulation and discuss their potential for modification of alloimmunity in transplant recipients. On d 21, FOS tended to increase the number of jejunal mucosa-associated lactobacilli in both the challenged and unchallenged birds. Rats were subjected to 45 min of ischemia and 48 h of reperfusion. We propose an explanation of the peculiar linear temperature dependence of the uniform spin susceptibility chi(T) in ferropnictides.

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Univariable and multivariable mixed models were used to assess the association between the Life Engagement Test and longitudinal sexual well-being. Less commonly, this condition may involve oesophageal and/or ocular mucosal surfaces, and case reports within the ophthalmology literature have recently confirmed the potential for this condition to affect the nasolacrimal ducts. Cardiac catheterization, angiography and echocardiography revealed a left atrial mass that was interpreted as atrial myxoma.

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Laser photobiomodulation as a potential multi-hallmark therapy for age-related macular degeneration. Quantitative questionnaire-based survey performed in five European countries on patients with asthma and COPD.

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In Group 2 anemia was found in all, neutropenia in one, and thrombocytopenia in two patients. The acquisition of biochemical data, especially the increase in speed of glycogen breakdown, when anatomical changes are not detected, represents an important result even when considering all the difficulties inherent in the process of translating experimental results into clinical practice. These experiments investigate the processes regulating the morphological differentiation of synaptic connections.

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In this work, it is shown how a tilt can be introduced into a segmented surface through several piston terms, by using the classical Ronchi test. GIGANTEA (GI), one of the key clock components in Arabidopsis, makes distinctive nuclear bodies like other nuclear-localized circadian regulators.

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QSAR modeling results elucidated that hydrogen bonds and electrostatic factors highly contributed to inhibitory activity, which was unanimous in the docking results. Nevertheless, potential hazards and health effects of THz exposure should be monitored carefully, particularly since some data suggest induction of genomic instability. Recently, various dermal substitutes have been developed to overcome this disadvantage of split-thickness skin grafts. In addition, CRH treatment induced rapid phosphorylation of p38 MAPK. Menin upregulates transcription of cell-cycle inhibitors to suppress endocrine tumors, but it is poorly understood how menin suppresses non-endocrine tumors such as lung cancer.

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Sequence variation of the alpha-lactalbumin gene in Holstein and Nellore cows. In addition to a visual approach, an automated procedure is introduced, which has the ability to rapidly scan through large numbers of suspicious image data in order to trace juvenile faces. We describe our initial experience using ProstaScint scanning in addition to conventional imaging modalities for staging of high risk prostate cancer. Their revocation has been under-investigated but is important because of the significant impact this process has on patients, families/carers and service-providers. In diseased joints expression is greatly increased both in articular cartilage and synovium.

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Orientation of the catfish in uniform and nonuniform electric fields. Apart from the selective effects on fiber caliber, the muscle tissue showed no signs of pathology, and apart from a characteristic slightly lower body weight, the transgenic animals looked and behaved normally. This study provides an overview of facial fractures in these age groups that helps illustrate the trends and characteristics of the fractures and may be helpful in further evaluation and management. The findings described here indicate that the presumably more phototoxic type II photosensitizer (MB) does not lead to higher degrees of cell death compared to the type I (CV) photosensitizer.

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None of the samples that we analyzed from target and non-target species contained quantities of ONRAB greater than 10(3)EU/mL of ONRAB DNA which is a limit that has previously been applied to assess viral shedding. As the technical aspects of MRI advance rapidly, and higher field strengths become available, it is hoped that the impact of MRI on our understanding of MS will be even more profound in the next decade. In this review, we discuss the emerging evidence for the in vivo signaling roles of EVs. Pathophysiological considerations open up new insights into that problem. Two reassortants isolated from the mixed infection with SA11 and S2 had a segment whose different migration in polyacrylamide gel was different from those of any RNA segments of the parent strains, suggesting the occurrence of rearrangement in the process of reassortment.

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We hypothesized that a high within-patient variability in clearance of tacrolimus and mycophenolate mofetil (MMF) would put patients at risk for periods of over- or underimmunosuppression and would thus lead to long-term chronic allograft nephropathy and graft loss after transplantation. These studies are of particular importance considering clinical trials, with either the soluble IL-4Ralpha subunit or a humanized anti-IL-5 antibody, are being conducted.

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The type of glass used to fabricate patch pipettes influences the kinetic properties of single-channel currents activated by acetylcholine in Xenopus myocytes. Characterization of novel dystonia musculorum mutant mice: Implications for central nervous system abnormality. Comments on the AZFc markers used for screening of Yq microdeletions. Only self-generated actions create sensori-motor systems in the developing brain. After referral, 35 patients did not attend the first visit in the healthcare center.

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Although linguistic debate continues about the exact formulation of such syllable models, the evidence is clear that listeners identify rhythmic beats at a particular point inside the syllable, namely at the release of the initial consonants into the following linguistically stressed vowels (referred to as the syllable peak, assumed to be part of the Nucleus). Histopathological evaluation was also performed in the nervous tissue to assess the axonal degeneration. Antiemetic-induced akathisia in cancer patients receiving chemotherapy.

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To develop an automated method of grading dry eye-associated ocular redness in order to expand on the clinical grading system currently used. In order to examine the real situation the determination of residue sulphite levels in ready-to-consume foods is required. The uptake of HES-FITC (200/0.5) was detected by fluorescence microscopy and flow cytometry. When bone marrow-derived monocytic cells were synchronized and stimulated to proliferate with CSF-1, c-fgr transcripts (but not transcripts from the highly related genes c-src or c-yes) were induced 8 hr after the addition of CSF-1 and decreased to low levels by 20 hr as the monocytic cells entered S phase.

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Guidelines for return to work of patients with infarction and coronary disease treated by angioplasty and/or by-pass Fifteen replicated pens were used for studying growth and feed conversion. Is the experimental naphthalene cataract a model for human senile cataract?

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Possible inhibitory influence of gamma-aminobutyric acid on growth hormone secretion in the rat. The first question regards how to elicit the EEG indexed hMNS during movement observation: Is hMNS activation best elicited using long stimulus presentations or multiple short repetitions?

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These extracellular cues activate CREB through phosphorylation at Ser133 by various protein serine/threonine kinases. Based on current data, carotid endarterectomy (CEA) should be performed in the majority of patients with symptomatic carotid artery stenosis.

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Concerning this problem, filtering methods for improving the power of detection of differentially expressed genes were proposed in earlier papers. Enhanced surveillance for pregnancy-associated mortality--Maryland, 1993-1998. Blood is the predominant infection source, yet HIV is also present in cerebrospinal fluid, pus, and other body fluids. The organ and tissue specificity of these and other invasive migrations through vascular endothelium may be related to the heterogeneity and organ specificity of endothelial cells. This hypothesis may add a new dimension to the understanding of MS etiology and help to design novel therapeutic agents against potential targets that might be discovered.

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The aim of this study was to validate the RUDAS in the Arabic language (A-RUDAS), evaluate its ability to screen for mild and moderate dementia, and assess the effect of education, sex, age, depression, and recruitment site on its performance. Additional studies of remitted LLD patients are needed to separate episode-related and persistent impairments.

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To the best of our knowledge, this is the first demonstration of biocompatible Janus nanoparticles that encapsulate a hydrophobic drug (paclitaxel) on one side and a hydrophilic drug (doxorubicin hydrochloride) on the other. We describe the use of polymerase chain reaction (PCR) to amplify Sarcoptes scabiei DNA in a patient presenting with clinically atypical eczema.

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protein was not, as was previously suggested, tropomyosin, but was a distinct Z-disc protein rich in proline. Zinc content in the diet affects the activity of Cu/ZnSOD, lipid peroxidation and lipid profile of spontaneously hypertensive rats. Inactivation of glutathione peroxidase following hemoglobin oxidation. It seems that these alterations are rare or absent in the Swedish population. This multicentre, phase 2 study investigated the effectiveness of MTD gemcitabine combined with metronomic capecitabine plus the multikinase inhibitor sorafenib for the treatment of metastatic renal-cell carcinoma (RCC).

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Shared Neural Mechanisms for the Evaluation of Intense Sensory Stimulation and Economic Reward, Dependent on Stimulation-Seeking Behavior. Plasmid standards of ERCC1, BRCA1, RRM1, TYMS and TUBB3 were established and standard curves were prepared by SYBR fluorescent real-time quantitative PCR analysis. In the practical valuation deviations of the sigma R-amplitude values which do not correspond to this relation should be referred to other determinants of the R-amplitude.

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The 60-kilodalton (kDa) form appeared similar to pp60c-src from cultured rat fibroblasts or astrocytes. Enhancement of neurotrophic activity in cholinergic cells by hippocampal extract prepared from colchicine-lesioned rats.

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Hierarchical modeling of genome-wide Short Tandem Repeat (STR) markers infers native American prehistory. We used Korean Census data (1995, 2005) and data from the National Death Files (1994-1996, 2004-2006) on education and employment status as indicators of socioeconomic position. The migration of eosinophils and lymphocytes, which were intensely positive for antilymphocyte function-associated antigen 1, was limited to follicular epithelium.

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We used orthogonal partial least-squares discriminant analysis (OPLS-DA) to distinguish between the DOR group and the NOR group of patients, and an OPLS model to predict the value of the oocyte mtDNA content that could be used as a critical marker of oocyte quality. Kinetic resolution of strand scission from base propenal release. The mycotoxin, deoxynivalenol (DON), is generally detected in cereal grains and grain-based food products worldwide. Quality of life in survivors of childhood cancer after megatherapy with autologous bone marrow rescue.

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Effect of librational motion on fluorescence depolarization and nuclear magnetic resonance relaxation in macromolecules and membranes. Within the heart, GATA transcripts are localized in ANP- and BNP-expressing myocytes, and forced expression of the GATA protein in heterologous cells markedly activates transcription from the natural cardiac muscle-specific ANP and BNP promoters. In addition to its roles in normal cell function, the inappropriate activation of Stat3 in tumor cells has attracted the attention of tumor biologists and has led to the consideration of Stat3 as a drug target. Seventy-two eyes of 72 patients diagnosed as PAC, having occludable angles with evidence of closure, but no ocular hypertension, were studied.

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Factors related to difficulties with employment in patients with multiple sclerosis: a review of 2002-2011 literature. Mast cells are instrumental in mediating anaphylaxis and patients with mastocytosis are at risk to develop provoked and unprovoked episodes of anaphylaxis. Any focal process may be to blame, but elderly sufferers generally have had vascular events, whereas the etiology is infectious or inflammatory in younger patients. Two entropic factors were identified as well: at the natural bending angle, water release and the quasiharmonic protein configurational entropy are maximized. The data were of observations made at the level of the catheter tip, which typically was located in the intrathecal space near the thoracolumbar region of the spinal canal.

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Strength of association of increased placental weight and smokeless tobacco use in pregnancy. To identify novel linkers connecting the two fragments, we investigated diamino-cycloalkane-derived analogs and discovered highly potent antagonists with cis-1,4-diaminocyclohexane as a unique spacer in this chemical class. The maximum observed correlation, which occurs at 1.1 MHz, yields a noise level 2.8 dB below the shot noise.

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Making nutritional information at fast-food restaurants more readily available and easier to use may help consumers to order more healthful or lower-calorie items. Moreover, it is suggested that photorespiration evolved in cyanobacteria before the origin of chloroplasts. The developmental competence of oocytes is not significantly different between early stage IVM and in vivo sibling embryos. Outcome measures were prosthetic and implant failures, and complications. New and interesting Laboulbeniales parasitic on Brazilian Diptera.

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In this work, ion channel simulations intended to model heteromeric neuronal nAChR are conducted under varying conditions of agonist presentation, and the impact of a key microscopic process, desensitization, is studied on the macroscopic responses. In contrast, the H waves still existed in 9 dogs of the AV node ablation group, the A waves dissociated with the H waves, the relationship between H waves and V waves was fixed, and H-V intervals were the same as before discharge.

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Therefore, regulation of the cell migration behaviours is of paramount importance in regenerative medicine. Because the experiment requires slow MAS rates, a novel recoupling sequence, designed using symmetry principles, is incorporated into the mixing period.

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A substituted anilino enaminone acts as a novel positive allosteric modulator of GABA(A) receptors in the mouse brain. Carbachol produced hyperactivity which was attenuated by the coinfusion of isoproterenol.

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During the last two decades, many large-scale randomized clinical trials have confirmed the importance of lowering blood pressure and inhibiting the renin-angiotensin-aldosterone system (RAAS) to preserve renal function in patients with chronic kidney disease due to different causes. Collection of samples in acyclovir 800 mg compresse prezzo oro SST tubes can offer considerable savings and specimen processing advantages for national level surveys. The results showed that at younger ages more posterior regions are involved in working memory processing, while in adulthood more anterior regions are involved. Extended lymphadenectomy with gastrectomy is widely performed for patients with advanced gastric carcinoma. It is suggested that the oocyte nucleus is not involved in the process of the oosome formation.

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For detection of granulocyte activation different assay systems were used: 1) lucigenin-dependent chemiluminescence (CL), 2) superoxide-dismutase (SOD) inhibitable cytochrome C-reduction (superoxide), 3) horseradish peroxidase-mediated oxidation of phenol red (hydrogen peroxide), 4) release of myeloperoxidase, 5) ultrastructural detection of hydrogen peroxide-production, 6) scanning and transmission electron microscopy (SEM and TEM). We conducted a detailed, area-specific analysis, measuring the thickness of articular cartilage and analyzing the distribution of Safranin O stain that binds stoichiometrically to GAG as determined by quantitative microspectrophotometry. Reduced glutathione (GSH), but not its oxidized form (GSSG), stimulated development of Onchocerca lienalis microfilariae to the late first-larval stage in vitro. In recent studies, ACL femoral tunnel drilling via a medial parapatellar or accessory anteromedial portal provides a more anatomic graft placement than transtibial putenbraten im baclofen medication femoral drilling. Induction of gene expression in sheepshead minnows (Cyprinodon variegatus) treated with 17beta-estradiol, diethylstilbestrol, or ethinylestradiol: the use of mRNA fingerprints as an indicator of gene regulation.

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We have studied the effects of bacterial microbiota in the lower genital tract on innate immunity and have found that Toll-like receptor ligands and short chain fatty acids, produced by bacterial microbiota, have dramatic effects on immune function. The tumor suppressor protein p53 plays an important role in apoptosis control as well as other cellular responses. The evolution of surgical oncologic technology has moved toward reducing patient morbidity without compromising oncologic resection. No significant difference was found in the WBC attendance rates of the index children and the controls. augmentin drug action of simethicone Magnesium metabolism in erythrocytes of patients with chronic renal failure and after renal transplantation.