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Kovar (Warfarin)
+ BONUS
 
Warfarin

Kovar is the main oral anticoagulant used in the UK. Oral means it's taken by mouth. An anticoagulant is a medicine that stops blood clotting. Clotting (thickening) is a complex process involving a number of substances called clotting factors. Clotting factors are produced by the liver and help control bleeding. They work with cells that trigger the clotting process (platelets) to ensure blood clots effectively. To produce some of the clotting factors, the liver needs a good supply of vitamin K. Kovar blocks one of the enzymes (proteins) that uses vitamin K to produce clotting factors. This disrupts the clotting process, making it take longer for the blood to clot.

Other names for this medication:
Warfarin, Coumadin, Aldocumar, Circuvit, Coumadine, Hemeran, Jantoven, Kovar, Marevan, Marivarin, Martefarin, Orfarin, Panwarfin, Simarc, Warafin, Warfarina, Warfarine, Warfin, Warin, Warlin,

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The abbreviated Barcelona Test (a-BT) is an instrument widely used in Spain and Latin American countries for general neuropsychological assessment. Despite pronounced preclinical cognitive deficits in dementia, the performance distributions between cases and controls are largely overlapping, hampering the ability to identify high-risk individuals.

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Two new acetylenic fatty acids (1, 2), a new triglyceride (3), along with eleven known compounds including 3-oxo-11alpha,12alpha-epoxyurs-13beta,28-olide (4) previously reported as a synthetic compound, have been isolated from the leaves of Hymenodictyon excelsum. Analysis of Chinese moxibustion in visible and infrared spectra in process of clinical application

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No difference was detected in the 8 SNPs investigated, which were distributed over the whole length of the gene. Thus, it is necessary to combine MS with spectroscopic techniques such as ultraviolet (UV) and NMR to achieve this objective. Kinetic studies showed that AAO is most active with p-anisyl alcohol and 2,4-hexadien-1-ol.

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The goals of this study were to determine whether nuclear androgen receptor (AR) concentrations in metastatic prostate cancer varied within and between specimens and to correlate this information with the response to therapy. The results suggest that concurrent expression of CD147 and MMP may be an important characteristic of PCa which may help in the prediction of PCa progression.

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How to routinely collect data on patient-reported outcome and experience measures in renal registries in Europe: an expert consensus meeting. A case of cerebrospinal fluid hypovolemia caused by Ommaya reservoir successfully treated by epidural blood patch

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Analyses point out that the peak interfacial strength for failure is the highest for supercells with plate shaped HAP crystals. However, little is known about the high-molecular weight active components conferring therapeutic properties to these extracts. Moreover, it was shown that gamma-cyclodextrin influences the equilibrium between mitomycin C and its zwitterion mesomer.

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Leber hereditary optic neuropathy (LHON) is a mitochondrial DNA (mtDNA) genetic disorder characterized by profound bilateral loss of central vision due to selective loss of retinal ganglion cells. The impaired release of plasma lipoprotein, increased fatty acid mobilization from adipose tissue, and enhanced fatty acid synthesis in liver have all been implicated as causative factors in the hepatic triacylglycerol accumulation occurring with experimental inositol deficiency. Evidently BMV protein does to some extent specifically recognise its own RNA molecules.

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Studies were undertaken at baseline and after the induction of limb ischemia. Immuno-capture as ultimate sample cleanup in LC-MS/MS determination of the early stage biomarker ProGRP.

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Substitution of either Cys22 with Gly, or Cys34-Gln-Val-Cys with His-Gln-Val-His, and deletion behind Lys50 of the tat protein caused a drastic loss in its activity. Molecular examination of bone marrow stromal cells and chondroitinase ABC-assisted acellular nerve allograft for peripheral nerve regeneration. Immunoprecipitation analysis using TBL2 deletion mutants revealed that the WD40 domain was essential for the 60S subunit association.

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kovar vs alloy 42

Out-of-hours maxillofacial trauma surgery: a risk factor for complications? The primary objective of this multicenter registry was to study the prognostic value of positron emission tomography (PET) myocardial perfusion imaging (MPI) and the improved classification of risk in a large cohort of patients with suspected or known coronary artery disease (CAD). In contrast, although her urinary excretion of phosphorous per hour was within the normal range in the basal state, she showed no proportional change in urinary phosphorous excretion with increase in urine cyclic AMP induced by administration of PTH(1-34). The presence of juvenile hormone had no effect on accumulation of either transcript. The Drosophila SWI/SNF counterpart, known as the Brahma or Brm complex, has been shown to have an essential role in regulating the proper expression of many developmentally important genes, including those required for eye and wing tissue morphogenesis.

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The increasing storage of vast amounts of information on computers and the rapidly increasing size of the databases stored on-line has the population and even many politicians worried about invasion of privacy. The complex constellation of individual, social, and environmental factors influencing transmission, require ecological solutions that recognize these multiple levels of influence and actively involve communities. TMPRSS12 Is an Activating Protease for Subtype B Avian Metapneumovirus. The programme sensitivity and the impact on prognosis of follow-up mammography with relation to compliance were evaluated in 114 patients who developed MCBC during hospital follow-up. Sarcopenia exists among elderly Chinese men and women, albeit at a lower rate than in white persons.

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The gating of the channel is analyzed and its relation to the gating current is proposed. These results indicate the possibility that the skin element is a cryptic remnant of an ancestral temperate phage.

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Patients participated in a communication intervention that incorporated use of a PSGD during their hospital stay. The key stage of this process is the formation and decomposition of N-centered radicals generated from the starting compounds. Use of partial least squares regression to impute SNP genotypes in Italian cattle breeds.

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Our findings provided evidence for at least three regions in the hsp72 which can be considered good candidates to represent T-immunogenic antigens. One-way analysis of variance tests were done to determine any significant differences between the bar-code and manual systems. The strategy of using the rapid antigen detecting test and a 10-day oral penicillin course for diagnosis and treatment proved to be the safest and most cost-effective. Rapid freezing and freeze substitution (RF-FS) have been used to re-examine the process by which the multinucleate sporangium of the Oomycetes, Phytophthora cinnamomi and P.

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Since ovarian cancer during pregnancy is rare, the decisions regarding pregnancy discontinuation or fertility preservation are often difficult. It is proposed that the complex behaviour of GaSb originates from a combination of spatially correlated evaporation events and the subsequent field induced dissociation of cluster ions, the latter contributing to inaccuracies in the overall atom probe composition determination for this material. Retrospective analysis of 132 cases of cardiopulmonary resuscitation based on a two-pages reporting form whose completion by the involved physician and intensive care nurse is mandatory after each event. Beta-blockers are commonly given to cats with heart disease, particularly hypertrophic cardiomyopathy, a common cause of feline heart disease. Although genetic and environmental factors are thought to contribute to the pathogenesis, there are only few examples in clinical or experimental systems that have identified specific causes.

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Increasing the amount of membrane-bound prothrombin retards the lateral protein and lipid diffusion, indicating coupling of both processes. Comparison of immunoprecipitations of LIMPs 1-4 from hepatocytes and NRK cells revealed a marked similarity in the proteins, in both cell types, as determined by SDS-PAGE. Moreover, simulated or dissimulated suicide is a possibility that must always be borne in mind in forensic practice.

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Use of this cost effective parameter may help identify patients with mild or no EV who may not need UGIE to reduce costs and discomfort for these patients and the burden on health system. Trypsin is the workhorse protease in mass spectrometry-based proteomics experiments and is used to digest proteins into more readily analyzable peptides.

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Thus the data needed to accurately model relative biological effectiveness to guide novel treatment planning approaches are limited. Synthesis and characterization of gold-nanoparticle-cored dendrimers stabilized by metal-carbon bonds. NDGA (0.5 microM) caused potentiation of PIA-induced relaxation. The aim of the present study was to identify and speciate Malassezia in patients clinically suspected of having Pityriasis versicolor.

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Immunochemical quantitation of thymine glycol in oxidized and X-irradiated DNA. The duration of after-discharge (AD) in the first generalized convulsion induced by electrical AM stimulation in the ME kindled rats was significantly longer than that in the first generalized convulsion induced by electrical stimulation in the saline treated control rats (P less than 0.05). In order to evaluate slimming effects on certain metabolic (cholesterol, triglycerides, basal insulinaemia) and haemorheologic (haematocrit, fibrinogen, whole blood viscosity and plasma viscosity) rates, we studied 24 obese subjects (15 female and nine male) aged 25-58, with BMI ranging from 35.5 to 67, before and after a hypocaloric diet period involving a 20-kg weight loss. The MGMT repair enzyme (O (6)-methylguanine-DNA methyltransferase) is an important factor causing chemotherapeutic resistance.

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Statistical analysis was carried out using the Mann-Whitney U-test and Poisson regression. The enzyme dosage, treatment time, treatment temperature, pH were optimized through orthogonal experimental design. Long-term tolerability and serum concentration of bevacizumab (avastin) when injected in newborn rabbit eyes.

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Chromosomal location, protein domain, motif organization, and phylogenetic relationships of 26 non-redundant GmHsf genes were analyzed compared with AtHsfs (Arabidopsis thaliana Hsfs). It is shown by examining the caustic surface for anumber of lens systems from the literature that the caustic is a valuable merit function for evaluating the aberrations and the size of the focal region.

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This indicates that this period is important in the formation of an immune defence system in the host. Product-moment correlations indicated a substantial relatedness among the the health indicators. In all groups with 30 microm cement thickness, the highest values were observed at the bottom surface.

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Two univariate methods, autocorrelation and curve-fitting, are used either as stand-alone methods or in combination to discover unknown metabolites in data sets originating from target-compound analysis. Carnitine was administered continuously via subcutaneous mini-osmotic pumps. In contrast, in deeply buried sediments below approximately 1 m depth, similar quantities of the 16S rRNA gene copies of these specific groups and Bacteria were found.

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Effect of sealing infected dentin with glass ionomer cement on the abundance and localization of MMP-2, MMP-8, and MMP-9 in young permanent molars in vivo. The Potential Application of Virtual, Augmented, and Mixed Reality in Neurourology.

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One of the characteristics of SAs is hypermaturation of the gland epithelium due to the low extent of cell loss by apoptosis. During exercise, sweat output often exceeds water intake, producing a water deficit or hypohydration. This study investigated adaptive differentiation and plasticity of prefloration intervals in the subalpine perennial Potentilla pulcherrima.

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Pleural effusion is a frequent complication in patients undergoing hemodialysis (HD). Similarly, instrumentation-induced variability sources of system stability and system-dependent response were also analyzed on skin and a nonvolatile biological tissue analog. Contrary to previous, intensity based segmentation algorithms, our method uses an intrinsic tissue property of the RPE: its depolarizing, or polarization scrambling effect on backscattered light.

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Perioperative oxygen supplementation and surgical site infection after cesarean delivery: a randomized trial. Reference gene selection for gene expression studies using RT-qPCR in virus-infected planthoppers. All the isolates utilized 13 carbon sources and three nitrogen sources tested and grew in a medium containing 3.7 M NaCl. The acute oral toxicity of hymenoxon is dose-dependent, and the clinical signs and pathologic lesions are qualitatively identical to those of animals fed whole bitterweed. The timing of differentiation of various components of the nephron corresponds to that seen during morphogenesis of other vertebrate kidneys.

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Cardiovascular adaptations in rats submitted to a resistance-training model. At this time we believe the use of hybrid, cementless diaphyseal-engaging stems should be considered as a possible option at the time of reimplantation. elegans appear to have strong similarities in human beings suggests that not only will C. The plant Stevia rebaudiana is well-known due to the sweet-tasting ent-kaurene diterpenoid glycosides.

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Design of multi-binding-site inhibitors, ligand efficiency, and consensus screening of avian influenza H5N1 wild-type neuraminidase and of the oseltamivir-resistant H274Y variant. Sequential biatrial linear defragmentation approach for persistent atrial fibrillation. This paper describes the functioning of a numerical P system and presents an overview of SNUPS capabilities together with an illustrative example. Our study was unable to replicate the findings of previously reported association for polymorphism rs7555523 in TMCO1 with POAG and related clinical indices such as IOP and cup/disc ratio indicating that this variant is not a risk factor for POAG in the Saudi cohort. These findings can provide useful information for understanding the drug resistance mechanism against vaniprevir and MK-5172.

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We have previously demonstrated how the growth of viruses in spreading plaques enables detection and characterization of their evolutionary dynamics. The control of cardiomyocyte apoptosis via the beta-adrenergic signaling pathways.

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We present 2 cases of sudden demise in the delivery room associated with atypical ductal anatomy with obstruction due to kinking and intraluminal intimal ridges. In the proliferation assay, cells were grown for four days and their proliferation rates were determined by regular impedance measurements. This study aims to assess the magnitude of the problem of fluorosis among 10-11 year old schoolchildren in a fluoridated area in Malaysia. Spermatogenesis in the xenograft of infant human testicular tissues proceeded successfully from the stage of spermatogonial stem cells until pachytene spermatocyte formation.

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Aneurysm occlusion and preserved distal vessel flow were confirmed with intraoperative angiography. Multimodal therapy for vertebral involvement of systemic mastocytosis. Long-lasting HIV infection and prolonged antiretroviral exposure are universally recognized in these patients. Long-range restriction map analysis performed with a field-inversion gel system shows that the six new loci are distributed in different places within 4p16. In the proximal part of the uterus, the egg has a discontinuous electron-dense layer, the external uterine layer.

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It is known, however, that patients will experience unfavorable side effects as the VEGF and/or VEGF receptor signaling pathway is also required for homeostasis in normal tissues. This increase disappeared after 8 days of withdrawal as did the animal preference for ethanol. We then correlated miRNA expression with post-recurrence survival and other clinicopathologic criteria. We will place emphasis on how these studies are beginning to discern the different roles played by anandamide and 2-AG in the nervous system and the resulting implications for advancing endocannabinoid hydrolase inhibitors as next-generation therapeutics.

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Cytolysis of tumor necrosis factor (TNF)-resistant tumor targets. The aim of radiotherapy for solitary plasmacytomas is to mainly relieve pain, rather than the curative local therapy. Partial purification and characterization of a protein in porcine follicular fluid which restricts sperm-egg interaction in vitro. Chronic pelvic pain in men has a strong relationship with biopsychosocial stress and central nervous system sensitization may incite or perpetuate the pain syndrome. For the health economic evaluation, the utilisation of continuous IC over 18 months was compared to the last 18 months prior to the inclusion in IC.

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Here we describe a proteomics separation tool, which uses a combination of continuous FFE, a liquid-based isoelectric focusing technique, in the first dimension, followed by rapid reversed-phase HPLC (1-6 min/analysis) in the second dimension. The therapeutic areas covered include cancer, inflammation, infectious diseases, cardiovascular, metabolic disorders, and miscellaneous areas such as polycystic ovary syndrome, allergic diseases, and so on. A bioabsorbable collagen nerve cuff (NeuraGen) for repair of lingual and inferior alveolar nerve injuries: a case series.

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Brassinosteroids (BRs) are involved in many developmental processes and regulate many subsets of downstream genes throughout the plant kingdom. Specifically, thin films of benzocyclobutene-functionalized random copolymers of styrene and methyl methacrylate were spin coated or transferred, then thermally cross-linked on a wide variety of metal, metal oxide, semiconductor, and polymeric surfaces, producing a coating with a controlled thickness and well-defined surface energy.

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The provision of EAAMR during caloric restriction-induced weight loss promotes the preferential reduction of adipose tissue and the modest loss of lean tissue in the elderly population. Focused ion beam (FIB)/scanning electron microscopy (SEM) in tissue structural research. N,N-Di-methyl-dehydro-abietyl-ammonium chloride ethanol monosolvate.

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Sparse LSSVM in Primal Using Cholesky Factorization for Large-Scale Problems. Impact of serum antibodies to p40tax gene product in the intrafamilial transmission of human T cell leukemia virus type I. Here we show that SPP signals through the EDG-1 receptor to the heterotrimeric G protein G(i), leading to activation of the serine/threonine kinase Akt and phosphorylation of the Akt substrate, endothelial nitric-oxide synthase (eNOS).

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This article will summarize areas of consensus reached by the group regarding many of the discussion topics. Deciphering the glycosylome of dystroglycanopathies using haploid screens for lassa virus entry. We reasoned that blocking this position would ameliorate toxicity, and that it might also enforce a favourable conformational switch of the trans-amide group into the cis-form required for protein binding. Both the false-positive rate of peptides and protein identification confidence scores were calculated in the present study. For men, there was no statistically significant association between household expenditure and cardiovascular risk factors.

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andreas kovar merck serono pharmaceuticals 2012-04-28

The Marfan syndrome is an autosomal dominant disorder with pleiotropic manifestations that involve the cardiovascular, ocular, and skeletal systems. Because symptoms are often vague and imprecise, a systematic approach is essential. There were no significant differences between groups in total anaesthetic requirements, as assessed by cardiovascular variables and movement. There clarithromycin 500 mg tablets side effects was good correlation between binding of the amide model to androgen receptor and the extent of purification by the affinity resin.

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Both of the strains have high virulence (as a result of enzyme and toxin production), what disturbs wound healing as well as a general condition of the patient. Seeing or feeling a vaginal bulge is the most specific symptom for identifying prolapse. Both racemic compounds are micromolar alpha-mannosidase (Jack bean) inhibitors. Endoscopic surgery can be used to the tumor with a base limited in the nasal cavity and sinuses buspirone mb3 555 pill in early time. Human tonsil lymphocytes were shown to be composed of heterogeneous cell populations with respect to the activities of cellular uptake of free fatty acids.

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DNA methyltransferase inhibition in normal human fibroblasts induces a p21-dependent cell cycle difference entre paroxetine et sertraline medication withdrawal. MEDLINE and EMBASE (1950-present) were searched in November 2007 and again in March and June 2008 to identify clinical trials, abstracts, and case reports involving ixabepilone. We also demonstrate that DBT interacts with PDP1epsilon and promotes its degradation by the ubiquitin-proteasome pathway in cultured cells.

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Incubation with L-arginine (L-Arg, 10(-3) M) caused a similar reversal of the inhibition of ACh-induced relaxation by L-NAME in both groups. Short- and long-term outcomes of hybrid interventions are at least comparable to conventional endovascular and surgical revascularization procedures. Patient perceptions of hospital discharge: reliability and validity of a Patient Continuity of Care ketoconazole 2% cream over the counter Questionnaire. Animal related injuries are frequently reported in India and other countries, where bulls are used for sporting events as well as in places where farming and livestock rearing is practised.

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The decrease of drug concentrations reflects the activation of orphan nuclear receptors by inducers that lead to the increase of the expression of enzymes and drug transporters. Genetic regulation of sn-glycerol-3-phosphate dehydrogenase in brown adipose zargus 2 mg ms tissue. Using a multiplex amplification and heteroduplex analysis of dystrophin exons, we identified nonsense mutations in two DMD patients.

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In this prospective cohort study, we estimated the effects of air pollution on mortality, while controlling for individual risk factors. Many patients with long-term mental illness considered their current quality of life to be reasonably good and were satisfied with the health care they received. Our results suggest that expression level is an important factor influencing the presence of tandem stop codons. This study quantifies the effect of bracing on kinematically constrained force exertions. Static urethrocystography cannot differentiate quitaxon 10 mg adderall women with and without stress urinary incontinence from among those with pelvic relaxation and thus should not be relied upon in the evaluation of women with urinary incontinence.

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Effect of alum-precipitated or oil-adjuvant Bacteroides nodosus vaccines on the resistance of sheep to experimental foot rot. The ghrelin O-acyltransferase-ghrelin system: a novel regulator of glucose metabolism. The patient was treated amotaks cena vs lesnar successfully with Levofloxacin as alternative treatment to penicillin. We speculated that this phenomenon may result from irritation of the affected brain and its surrounding areas, since the episode took place following the seizure.

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Since social interaction results in brain and body heat production, coupled with skin vasoconstriction that impairs heat loss to the external environment, these physiological changes interact with drug-induced changes in heat production and loss, resulting in distinct changes in the hyperthermic effects of each tested drug. These receptors serve as therapeutic sites for general anesthetic, antipsychoactive, antinociceptive, and anxiolytic drugs in the brain. To characterise the disease in patients with mutations in RPE65. The neutralization of G-CSF bioactivity with anti-G-CSF antibody abrogated this effect. This study aimed to evaluate the outcomes in patients undergoing balloon-assisted herperax tablets at best enteroscopy (BAE) with heat probe or argon plasma coagulation and to identify risk factors for recurrent bleeding.