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Tolterodine
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Tolterodine

Tolterodine Tablets contain Tolterodine tartrate. The active moiety, Tolterodine, is a muscarinic receptor antagonist. Tolterodine tartrate is a white, crystalline powder. The pKa value is 9.87 and the solubility in water is 12 mg/mL. It is soluble in methanol, slightly soluble in ethanol, and practically insoluble in toluene. The partition coefficient (Log D) between n-octanol and water is 1.83 at pH 7.3.

Other names for this medication:
Tolterodine, Detrol, Roliten, Detrusitol, Flochek,

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Chronic hyperplastic parathyroiditis: the anatomico-clinical and pathogenetic aspects A report on three necropsied cases, with observations on the laryngeal muscles and the nuclei ambigui. Biochemical analysis of this region revealed that the histochemical activity was mainly due to the A12 form.

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Health literacy and its association with diabetes knowledge, self-efficacy and disease self-management among African Americans with diabetes mellitus. In spite of the vital role CT plays in the evaluation of vascular disease, no standard CT derived dimensions for the abdominal aorta, iliac, and femoral arteries have been established. Thus, the primary sources of IFN-beta in recurrent herpes lesion vesicles are the virus-infected keratinocytes. Use of a single-centrally located monitor, the arithmetic average, the nearest-neighbor monitor, and the inverse-distance weighted average surrogates resulted in biased estimates and poor coverage rates, especially for larger magnitudes of the association. They discuss both the unique features of alcoholic liver fibrosis and the similarities to liver fibrosis from other etiologies, and review molecular pathogenesis and animal models.

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The distal clavicle displacement, peak stress, and stress distribution on the 3 finite element models were calculated under the axial compression and cantilever bending. The results of operative treatment of 122 patients for stenosing diseases of the esoph- agus during 1993-2014 yrs period were analyzed. Preterm birth remains one of the most important issues facing perinatal medicine today, with chronic inflammation and/or infection being the biggest etiological factor. Hospitalized patients with atrial fibrillation compared to those included in recent trials on novel oral anticoagulants: a population-based study.

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This work indicates that the gap junction communication and the oxygen threshold of turning survival signals into apoptosis can notably affect cancer progression. Systematic spin-trapping studies of peroxynitrite decomposition in the presence of glutathione established that DMPO-hydroxyl radical adduct formation was metal independent, occurring in a metal-free buffer and being unaffected by diethylene-triaminepentaacetic acid. But in the course of the investigation, we and other groups identified a large subgroup of patients who had a less severe form of orthostatic intolerance characterized by postural tachycardia, lightheadedness, dizziness, and chest discomfort, etc.

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It could be probably prevented by careful insertion of an appropriate size LMA, and the use of low intracuff pressures and/or volumes. Anti-HBs antibody of normal human subjects predominantly binds 54 K and 60 K dalton HBs polypeptides. Arterial pressure and plasma lipids in Moscow schoolchildren 16 to 17 years old (based on data from a single epidemiologic study)

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Clot retraction, measured by the down slope on the Sonoclot signature, decreased significantly in group-1 patients, although values obtained for both groups were in the normal range. Multiplex PCR/RT-PCR methods were used to target 18 major common respiratory viruses. This should include confirmation of the diagnosis with CT imaging, lumbar puncture or both, and recognition of the complications of subarachnoid haemorrhage, which include hydrocephalus, further haemorrhage and cerebral vasospasm. These seven key lessons, which focus heavily on needs assessment as well as team working and the need to consider a multiprofessional approach, offer practical advice to those in the medical and dental professions wishing to produce their own educational programmes. As lignocellulosic biomass deconstruction for biofuel production remains costly, natural GH diversity offers a starting point for developing industrial enzymes, and fungal GH family 7 (GH7) cellobiohydrolases, in particular, provide significant hydrolytic potential in industrial mixtures.

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Survival and complication rates of implant-supported fixed partial dentures with cantilevers: a systematic review. The Rab-regulated processes of cargo sorting, cytoskeletal translocation of vesicles and appropriate fusion with the target membranes control cell metabolism, viability, growth and differentiation. MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation. In addition to low macrophage inflammatory responses, A/J mice had fewer resident peritoneal macrophages. Six generations from a large MEN-1 family pedigree were studied.

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We reviewed retrospectively 101 consecutive patients with bilateral intrahepatic stones who underwent bilateral liver resection in the past 10 years. Central nervous system (CNS) infections are among one of the most common complications in HIV-infected patients. For prostate cancer, the fraction burden for 2012 varied from 4874 fractions per million in Tower Hamlets PCT to 23 181 fractions per million in Lincolnshire PCT (national mean - 15 087 fractions per million). qEASL is a robust method with comparable values among tested placements. The importance of total kidney volume in evaluating progression of polycystic kidney disease.

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Polyclonal keratin antibody (TK, detecting 41 to 65 kDa keratin) and monoclonal antibodies KL1 and PKK1 (55 to 57 kDa and 41 to 56 kDa, respectively) were used. An immunohistochemical analysis of six cases and comparison with other epithelioid neoplasms of soft tissue. Taxanes and anthracyclines are active in TNBC and remain important agents but have not shown specific benefit over non-TNBC.

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A mitochondriotropic derivative of quercetin: a strategy to increase the effectiveness of polyphenols. A stable isotope of copper was intravenously administered to 6 men, and fecal samples were collected for 14 d. Herein, we report the case of a 65-year-old man with type 5 skin who presented with an unusual and extensive involvement of the scalp and face presenting a diagnostic challenge.

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Prognostic biomarker value of binary and grayscale breast tumor histopathology images. Furthermore, in the zymosan model of acute inflammation, mechanical allodynia was attenuated, and microglial response was less robust in 22 compared to 3-month-old mice. Tissue transparency was significantly higher than control non-decellularized tissues for all protocols, although the best light transmittance results were found in tissues decellularized with SDS and triton X-100. The effects of environmental covariates on population dynamics also varied latitudinally, particularly for mallard, northern pintail and northern shoveler. Radial artery mass was validated in vitro by comparing the weight of arterial segments to the ultrasonographic determination of their mass, calculated as: rho L(pi Re2-pi Ri2), where rho is the arterial wall density, L the length of the arterial segment, and Re and Ri the ultrasonic values of internal and external radii, respectively.

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Lymphocytic adenohypophysitis: clinical, radiological, and magnetic resonance imaging characterization. Location of terminal methyl groups of acyl chains in the bilayer of unilamellar phosphatidylcholine liposomes: a 13C-NMR study. These signal correction methods were evaluated by classifying fused near- and mid-infrared spectra of French olive oils by geographic origin. Radiolabeled precursors were efficiently incorporated and further metabolized in isolated chromoplast. Neither massed nor spaced conditioning ameliorated the attenuation of tone-dependent freezing.

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Evaluation of periodontitis treatment effectiveness based on indices of the activity of neutrophil elastase and its acid-stable inhibitor in the oral fluid of patients We present an estimate of the kappa-coefficient of agreement between two methods of rating based on matched pairs of binary responses and show that the estimate depends on the common intraclass correlation coefficient between the pairs. Tribolium uses an intermediate strategy that has commonalities with both Drosophila and zebrafish.

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Domestic use of hypochlorite bleach, atopic sensitization, and respiratory symptoms in adults. Ex situ IRRAS and X-ray photoelectron spectroscopy were applied for the analysis of the adsorbed self-assembled monolayers. Previous studies have suggested that some AML cells can produce their own CSFs, but the frequency of this phenomenon is unclear. In conclusion, both manual pointing and perceptual judgements are susceptible to the well-known Poggendorff effect, supporting the notion of a unitary representation of space for action and perception or else an early locus for the effect, prior to the divergence of processing streams. Effect of dose on the kinetic behaviour of valproic acid: modifications in plasma protein binding.

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In protein synthesis, threonyl-tRNA synthetase (ThrRS) must recognize threonine (Thr) from the 20 kinds of amino acids and the cognate tRNA(Thr) from different tRNAs in order to generate Thr-tRNA(Thr). Information coding in vasopressin neurons--the role of asynchronous bistable burst firing. Phonation of sustained vowel /a/ was subjected to acoustic analysis using Computerized Speech Lab (CSL model 4150) software.

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Intrasphenoid rupture of a non-traumatic aneurysm of the cavernous carotid artery is rare. Mitogen-activated protein kinase expression and activation does not differentiate benign from malignant mesothelial cells.

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The pH-rate profiles indicated a three-deprotonation process with pK(a) values of 4.3, 7.2, and 9.1. Evidence that vascular endothelial cells can induce the retraction of fibrin clots. Transforming growth factor-beta stimulates trophoblast oncofetal fibronectin synthesis in vitro: implications for trophoblast implantation in vivo. The application of pharmacogenetics in testing individual polymorphisms of two genes CYP 2C9 (pharmacokinetics of warfarin) and VKORC1 (sensitivity on warfarin) is promising tactics leading to a safe anticoagulation.

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In contrast, the two regions did not differ in the probability of damage by herbivores, which did not select flowers based on any of the measured traits, nor affected maternal fecundity. Impact of Delta Hemoglobin on Provider Transfusion Practices and Post-operative Morbidity Among Patients Undergoing Liver and Pancreatic Surgery. This study examines the relationship between the aggregation response, ATP release and the platelet count in a lumi-impedance system. That embryonic, fetal, and adult globins were coexpressed by cells of the same lineage was documented by analysis of globin chains in single BFUe colonies: all 67 yolk sac-origin BFUe colonies and 42 of 43 liver-origin BFUe colonies synthesized epsilon-, gamma-, and beta-chains.

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Surface expression of P-selectin on activated platelets induces formation of platelet-monocyte aggregates and promotes vascular inflammation and thrombosis. Further studies may reveal the exact causes of these differences. Tissue factor (TF), the primary initiator of coagulation, is often overexpressed in malignancy and as such is a prime candidate in predicting the hypercoagulable state. The eumelanin-related metabolite 6-hydroxy-5-methoxyindole-2-carboxylic acid (6H5M12C) is also excreted at high levels in some melanoma patients.

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Effects of hypoxia on stress proteins in the piglet heart at birth. The role of endothelium in the pathogenesis of diabetic microangiopathy. Dynamics of changes of cytogenetic indices after a heavy trauma show that the traumatic shock may exert a cytogenetic effect maintaining for 18 hours. We report on a 62-year-old man referred to the cardiac intensive care unit less than 24 hours after anterior ST-segment elevated myocardial infarction. Etiologic and therapeutic considerations mentioned in literature are discussed.

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