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The effect of specific inducers on the biosynthesis of lytic enzymes by a strain of Streptomyces recifensis var. The algorithms are implemented in a new version (version 2.1) of the software package GENEHUNTER. Quantitative pathology of coccidioidomycosis in acquired immunodeficiency syndrome. Heterogeneity of the population of Escherichia coli thr- by assimilation of 3H-threonine

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Advances in our ability to measure RNA expression have resulted in a gradual increase in the number of identified housekeeping genes. Targeted agents for HNSCC expected to improve the effectiveness of current therapy including HER family, Src-family kinase, cell cycle, MET, AKT, HDAC, PARP, COX inhibitors and antiangiogenesis. Although head and neck masses represent a common entity in children, malignancy is uncommon. After the onset of viral DNA synthesis predominant cytoplasmic transcripts represented more dispersed areas of the genome, particularly those regions which were only weakly transcribed earlier after infection. Establishment and characterization of two new squamous cell carcinoma cell lines derived from tumors of the head and neck.

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As new functional, candidate genes for keratoconus are being discovered at a rapid pace, the molecular genetic mechanisms underlying keratoconus pathogenesis will advance our understanding of keratoconus and promote the development of a novel therapy. The objective of the present investigation was to compare cardiovascular risk factors and psychosocial work characteristics of surgeons and general practitioners, the latter having a substantially lower rate of ischemic heart disease. A meta-analysis of clinical outcome in patients with total intestinal aganglionosis.

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Traditional ochratoxin A(OTA) competitive antigen are high toxicity, high price and difficult preparation. During February-May 1992, a sample of Melbourne GPs filled in a questionnaire concerning their screening practices, and the results were correlated retrospectively with results of Pap smears taken in March and October 1991. Fish fed 10 and 100 mBq/g(-1) diet showed a small transitory deregulation of growth at 6 and 12 months. Negative SIRT1 regulation also alleviates gene-repression associated with fragile X mental retardation syndrome. A 21-year-old febrile woman with sudden onset of headache and semicoma was transferred to our institute.

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The purpose of the present investigation was to determine the effectiveness of the Myo in reducing plaque and gingivitis development in orthodontic patients using a single-blind, cross-over design. We demonstrate a novel PAM design that markedly simplifies the implementation by separating the optical illumination from the acoustic detection path. The adenocarcinoma had been treated using all available oncology therapeutic modalities. Investigation of the impact of systematic videorecording of colonoscopy on quality, cost, and medical-legal risk is warranted.

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Moreover, pro-atherogenic stimuli such as oxidized low density lipoprotein led to an inactivation of Akt and diminished telomerase activity. It might be recognized best, if cardiac function is correlated to afterload. Shedding of CMV in the saliva of AIDS patients occurs despite the presence of serum antibodies with a high capacity to neutralize autologous CMV isolates.

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Upon incorporation of cholesterol, tumor cells, which are exemplified here by colon and gastric carcinoma cells, become substantially more immunogenic and therefore more susceptible to clearance by the immune system. To circumvent hormone resistance, intermittent androgen suppression was investigated as an alternative treatment option. Sympatho-adrenal hyperreactivity to footshock stress but not to cold exposure in spontaneously hypertensive rats.

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Characterisation of normal and cancer stem cells: one experimental paradigm for two kinds of stem cells. In harmonization to ethical codex, the physician is obliged to inform the patient about the origin of medical error. Lipocalin-type prostaglandin D(2) synthase stimulates glucose transport via enhanced GLUT4 translocation. Isolation method for a stem cell population with neural potential from skin and adipose tissue.

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Biotinylation on the maleimidated surface was confirmed by X-ray photoelectron spectroscopy. It was proved that the effect of the anode surface roughness could not be modeled by simple filters made from the anode material.

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While the occurrence of heterotopic ossification has previously been reported when rhBMP-2 has been used for spinal fusion surgery, this case demonstrates that it can occur to a much greater degree than previously seen. Reconstructing a physical map of a chromosome from a genomic library presents a central computational problem in genetics. The processes of compensation and habituation in the S1 zone of the cerebral cortex in response to stimulation of the pelvic nerves were studied in experiments with anesthetized and immobilized cats. A patient with a red, painful eye and gradual visual impairment is examined ophthalmologically.

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A real-time polymerase chain reaction (PCR) assay quantified the effect of ORF50 on the transcription of E6 and E7 within these cells. As a sequel to the article by Ken Lambert and Tara McKeon, we propose a model by which defects in lead aprons may easily be evaluated on a routine basis. Results of this study showed that, with the assistance of EAPAP, participants can position targets quickly, easily and accurately, thus helping the disabled to solve their pointing problems. Bugs collected from domiciles and/or storerooms had significantly larger right-wing centroid size than bugs collected at goat and/or pig corrals by the end of summer 2000 for both sexes. It highlights work from our laboratory, focusing mainly on new aspects of P-selectin and CD40L (CD154) biology and on the interplay of platelets and leukocytes in thrombosis and inflammation.

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the aim of this study was to investigate specific activation patterns and potential gender differences during mental rotation and to investigate whether functional magnetic resonance imaging (fMRI) and functional transcranial Doppler sonography (fTCD) lateralize hemispheric dominance concordantly. LC50 values of 4.76 mg/L NA were found for tadpoles at an early developmental stage (Gosner stage 28), and even greater toxicity with more developed tadpoles at 96 h, with an LC50 value of 3.04 mg/L in Gosner stage 36 tadpoles. Characterization of a glycosyl-phosphatidylinositol degrading activity in Dictyostelium discoideum membranes.

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The ability of the hypomethylating agent 5-azacytidine to transform normal primary rat tracheal epithelial cells was determined. Here, we examined the functional role of adenomatous polyposis coli-like molecule 2 (APC2) in the development of axonal projections by using the chick retinotectal topographic projection system.

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The thermal processes, which occur on the phase boundary and are possible in the absence of gravity force, lead to the generation of weakly decaying periodic waves of low amplitude, whose velocities may exceed significantly those of gravity waves. Influence of climate and reproductive timing on demography of little brown myotis Myotis lucifugus. Since the results from single studies are inconclusive, a systematic review was undertaken. Stool specimens obtained from 1056 children complaining of diarrhoea were cultured on plating media and on enrichment media. Calcineurin (CaN) is a calcium/calmodulin-dependent phosphatase directly activated by calcium as a result of neuronal activation that is important for neuronal function.

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These data suggest that RNA-binding proteins can be used as a tool to identify the post-transcriptional regulation of gene expression in the establishment and function of neural circuits involved in addiction behaviors. Dissemination of relevant findings to prosecutors will facilitate optimization of referral to therapeutic jurisprudence programming and the matching of offenders to services. Traumatic aortic-left ventricle tunnel through interventricular septum was particularly a rare event that has never previously been described. This mechanism plays a great role in hair pigmentation especially in dominant (ED/ED) and recessive (Aa/Aa) black lambs of all investigated breeds.

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The SLC4 and SLC26 proteins are important contributors to transepithelial movement of fluids and electrolytes and to cellular pH and volume regulation. To investigate the impact of pain intensity, pain catastrophizing and depressive symptoms on the level of physical activity and disability of adolescents and young adults with chronic pain. We aimed to test various types of rTMS in a large sample of depressed patients following EBM rules and to investigate treatment-related changes in plasma levels of neurotransmitters involved in depression.

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Intravitreal administration of AAV vectors, which resulted in transduction of inner retina (primarily retinal ganglion cells), generated a humoral immune response against AAV capsid that blocked vector expression upon readministration via the same route into the partner eye. More cases of posterior bleeding are needed for future studies involving multivariate analyses and appropriate analyses of factors related to hospitalization, surgery, and embolization.

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The results show that methionine depletion increases the resistance of tumour cells to the chemotherapeutic agents tested. A structurally flexible and antigenically variable N-terminal domain of the hepatitis C virus E2/NS1 protein: implication for an escape from antibody. To determine whether Helicobacter pylori eradication is an effective treatment for Australian patients with chronic immune thrombocytopenic purpura (ITP). The partial suppression of ln and ash coat colors is associated with the partial restoration of normal melanocyte morphology.

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This method was used to detect the activity of as little as 0.6 mU of purified TG2, and can be used for detection of activity from crude cellular lysates. p53 expression in pseudoepitheliomatous hyperplasia, keratoacanthoma, and squamous cell carcinoma of skin. Recent data revealed that HIV-1 nucleocapsid restricts reverse transcription during virus assembly--a process called late reverse transcription--suggesting a regulation between RNA packaging and late reverse transcription. The inclusion of multiple genes in the diagnostic panel, combined with the superior sensitivity and broader dynamic range of RNA-Seq, has the potential to improve the accuracy of bTB diagnostics.

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The early lactation period of dairy cows, which produce high quantities of milk, is normally characterized by an insufficient energy intake to cover milk production and maintenance requirements. Adjunctive dietary drug therapy may be useful for clinicians working with obese patients in long-term weight loss trials, and may show promise in the treatment of bulimia. Indeed, it can be assumed that in most instances the initiation event is due to a mutation which causes inactivation or loss of a mutation avoidance gene, such as the p53 gene, or a gene which is involved in the repair of damaged DNA.

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A comparison of the epidemiology of bovine ephemeral fever in South Korea and south-western Japan. Gender differences were examined in health status and HIV care among HIV-infected minority drug users. Shrimps have been a popular raw material for the burgeoning marine and food industry contributing to increasing marine waste. Calculations are made of metallic reflective phase shifts, from the midvisible through ir, showing that this rotator would introduce negligible elliptical polarization for wavelengths longer than about 5 microm.

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Between 2 and 4 h, Plato and Plant gave recovery ratios of 1.8-2.3 and 1.6-1.9, respectively. We show that reactive oxygen species induce the formation of cysteine-thiol disulfide-dependent complexes of FoxO and the p300/CBP acetyltransferase, and that modulation of FoxO biological activity by p300/CBP-mediated acetylation is fully dependent on the formation of this redox-dependent complex. We have characterized the changes in tissue concentrations of amino acids and biogenic amines in the central nervous system (CNS) of mice with MOG(35-55)-induced experimental autoimmune encephalomyelitis (EAE), an animal model commonly used to study multiple sclerosis (MS). These results suggest that gestational diabetes altered neonatal plasma lipoprotein metabolism. Together, these data support a neuropathological model in which sleep disruption may contribute to the maintenance and/or exacerbation of anxiety through its impact on anticipatory brain function.

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Haemodynamic effects of a propofol-sufentanil infusion for sedation in the ICU following coronary artery surgery. The restricted distribution of retinoic acid in the rat brain suggests that this vitamin could be involved in very specific physiological mechanisms. With NCRC-11 defined antigen from breast carcinoma, this determinant was totally masked by sialic acid although neuraminidase treatment clearly exposed epitopes reactive with M18 antibodies. Labeled terminals were also occasionally seen in the caudal medial pontine nuclei.

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In agreement with previous findings, low doses of apomorphine induced a syndrome of vacuous mouth movements, penile grooming, yawning and immobility whereas at higher doses the yawning syndrome disappeared to be replaced with sniffing, licking and gnawing. Warm ischaemia for 1 h followed by reperfusion for 24 h caused mild pancreatitis in this experimental model.

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These data indicate that Pb-exposure can accelerate the degradation of the cultured lens through induction of epithelial cell abnormalities, induce structural protein modifications before opacity, and predispose the lens to opacification with subsequent oxidant challenge. Next the health care professional smart card is presented as the solution chosen in France. The HGF/SF-Met signaling pathway is frequently activated in a variety of cancers, and uncontrolled Met activation correlates with highly invasive tumors and poor prognosis. Clinicopathological factors and outcomes were compared between the groups. This study explored the association between micronutrients and uterine fibroids.

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MCM proteins play a role in maintaining genome integrity and prevent re-replication once per cell cycle. The stepwise N-methylation of phosphatidylethanolamine (PE) to phosphatidylcholine (PC) (phospholipid methylation) was assessed in cardiac sarcolemma and sarcoplasmic reticulum of aging rats. In independent field and laboratory studies, a measure of Dscam splice-form diversity was compared between mosquitoes fed on blood that was free of P. Our results suggest that in Europe during these two periods democratization has had mixed effects. To investigate the prevalence of hazardous alcohol and drug use in a Swedish psychiatric outpatient population with particular focus on hazardous alcohol consumption and assess relationships of hazardous alcohol use to sex, age and psychiatric diagnosis.

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Our results evidently indicated that Cu resistance of the copepod was increased even after one generation of acclimation to 100 microg Cu l(-1). Oral treatment with the NADPH oxidase antagonist apocynin mitigates clinical and pathological features of parkinsonism in the MPTP marmoset model.

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Agarose gel electrophoresis of retinal DNA isolated from animals 25, 30, 35, and 40 days old showed a ladder pattern of degradation with bands corresponding to multiples of 180 to 200 base pair subunits. Breast carcinomas with immunocytochemical detection of aromatase in fine-needle aspirates: report of three cases. None of the 52 pregnancies were complicated by venous thromboembolism. NASHA was injected using a standardized technique with nerve block anesthesia to ensure patient comfort. Factors associated with vaccination for hepatitis B, pertussis, seasonal and pandemic influenza among French general practitioners: a 2010 survey.

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These data suggest that miRNAs are critical participants in necroptosis and miR-21 enhances cellular necrosis by negatively regulating tumour suppressor genes associated with the death-receptor-mediated intrinsic apoptosis pathway, and could be a therapeutic target for preventing pathologic necrosis. Data on birth weight for gestational age (GA) are not well described for infants with trisomy 21 (T21), trisomy 18 (T18), or trisomy 13 (T13).

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Subjects more likely to demonstrate cognitive impairment after 24 weeks of treatment can be identified early on during treatment (i.e., within 6 weeks). A double-blind, parallel, placebo-controlled study was performed to assess the efficacy of a combination drug product containing the antihistamine, triprolidine, and the sympathomimetic, pseudoephedrine, in the treatment of allergic rhinitis. Congenital aplasia cutis: nonsurgical treatment with a synthetic skin substitute. solanacearum chromosome, however, we observed no effect on growth in culture or on exopolysaccharide production. CodY and CcpA have been shown to regulate expression of branched-chain amino acid biosynthetic genes, suggesting that the ability to sense carbon flow and the nutritional state of the cell also plays a role in the regulation of ilvE.

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Moving beyond the classification of advocacy efforts to measurable indicators and outcomes of policy, therefore, requires a dynamic research approach. In addition, GFP-positive duodenal mucosa was observed in all cases by immunohistochemical staining.