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Duraject (Dapoxetine)

Duraject a selective serotonin reuptake inhibitor is a new chemical entity for the treatment of premature ejaculation. Since no systematic studies on design and development of Duraject hydrochloride tablets are available in literature, we propose to develop a suitable formulation to characterize in vitro release profile of Duraject hydrochloride. The aim of the present study was to formulate various formulations of immediate release tablets of Duraject Hydrochloride using different excipients by direct compression and wet granulation method. The granules and tablets of Duraject HCl were evaluated for various pre and post compression parameters like Angle of repose, Compressibility index, Hausner's ratio, Tablet hardness, Thickness, Friability, and chemical parameters. Punches of different size were used to obtain the desired shape, ease of swallowing of tablets, to improve aesthetic value in terms of appearance and shape of tablets. To match dissolution profile of test formulation with innovator, drug particle size is reduced from D 90-158 µ to D 90-45 µ, which resulted in an increased surface area exposed to the dissolution medium. Final formulation was evaluated for multimedia dissolution in three different media and dissolution data was found satisfactory. Accelerated stability studies conducted for 2 Months at 40°C and 75% RH and were found within specification.

Other names for this medication:
Dapoxetine, Actinex, Aczone, Dapoxetin, Dapoxetina, Dapsone, Dejac, Duraject, Duralast, Poxet, Priligy, Viglast, Westoxetin, Xydar,

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The clinical information acquired by 3D SA and the consistency of virtual and real hepatectomy were evaluated. The main factor in determining the mechanical properties of bone is the collagen configuration. A key to the known species of Laetiporus in the northern hemisphere is provided. The importance of monitoring and maximizing treatment fidelity in public health research. The ambulatory arterial stiffness index (AASI), derived from ambulatory blood pressure monitoring (ABPM) recordings, has been proposed as a surrogate marker of arterial stiffness.

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Methods of treatment in patients with lower extremity arterial occlusive disease in presence of distal arterial lesion(Part 1) No significant difference was observed between the control and XFS group. Current options of prenatal diagnosis in congential diaphragmatic hernia

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Jeffrey Bernard claims that he lives an unremarkable life - and earns a living writing about it as a regular columnist for The Spectator. Effect of composting poultry carcasses on survival of exotic avian viruses: highly pathogenic avian influenza (HPAI) virus and adenovirus of egg drop syndrome-76. The vascular space shrinks to normal after adequate resuscitation, creating relative hypervolemia.

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Single-day famciclovir (1000 mg administered twice daily) was similar to 3-day valacyclovir (500 mg administered twice daily) in both efficacy and safety, representing a more convenient treatment for immunocompetent adults with recurrent genital herpes. Surfactant alterations are described in horses after exercise, anesthesia, and prolonged transport, in horses with recurrent airway obstruction, and in neonatal foals. Structure elucidation of these metabolites was based primarily on 1D and 2D NMR analyses.

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Imaging of tumor-related, pathologic fractures - differentiating primary and secondary bone tumors Data was anonymously collected on clusters through the statutory health insurance. Using the derived equation for the LP modes, numerical calculations have been made by varying parameters such as fiber and jacket parameters, wavelength, and mode power distribution. Three-year study of cervical erosions restored with resin and dentin-bonding agent.

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In the supine position, the effect of pumping was observed to increase the volumetric flow at a rate similar to or higher than that yielded in the free-flow tests. Quantification of aquabirnaviruses isolated from different host species by real-time RT-PCR.

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The 2 cases direct our attention to at least 3 important points regarding safe administration of ECT shortly after the occurrence of PE, that is, careful evaluation of cardiac function and residual deep vein thrombosis before the start of an ECT course, adjustment of anticoagulants, and prevention of recurrent deep vein thrombosis and PE by methods in addition to anticoagulant therapy (fluid infusion, use of support hose, and timely ECT). Traditionally, the measures have been mortality and morbidity, but they now also include assessment of indices such as functional status, health status, quality of life and patient satisfaction. Immediate or delayed breast reconstruction is usually performed using expansion techniques or pedicled or free flaps. In this study, the effects of acute ammonia intoxication in vivo on brain adenine nucleotide pool and xanthine and hypoxanthine, the end degradation products of adenine nucleotides, during the conversion of XD to XO were studied. Ancylostoma braziliense is most often implicated in dermatological lesions, and Ancylostoma caninum has been associated with eosinophilic enteritis and suggested as a possible cause of diffuse unilateral subacute neuroretinitis in humans.

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In the past decades, both the increasing experimental evidences and some results of theoretical investigation on non-Kolmogorov turbulence have been reported. The risk of resistance development to fludioxonil and the potential implications of resistance mutations to ochratoxin production in Aspergillus carbonarius were investigated. During the stimulatory phase of GnRH action, both subunits rise concordantly, but during the down-regulatory phase the secretion of the two subunits becomes unbalanced.

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Interleukin 12 delays allograft rejection: effect mediated via nitric oxide. Two one-day training courses run separately for 13 social-care practitioners and 10 health-care librarians in the Trent geographic region within Northern England. Prior research suggests that acoustical degradation impacts encoding of items into memory, especially in elderly subjects. In situ formation of porous space maintainers in a composite tissue defect. The field induces a complex reaction between the membrane and the plasmid that is accumulated at the cell interface by electrophoretic forces.

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An automated method to determine angular preferentiality using LFPs recorded from rat barrel cortex by brain-chip interface under mechanical whisker stimulation. The primary endpoint was long-term major adverse cardiac events (MACE) with all-cause mortality a secondary endpoint. ACCF/AHA clinical practice guideline methodology summit report: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines.

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Control of the cardiac action potential: The role of repolarization dynamics. MDMX is thought to function as an oncoprotein by binding p53 tumor suppressor protein to inhibit p53-mediated transcription, and by complexing with MDM2 oncoprotein to promote MDM2-mediated degradation of p53.

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