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Karum (Clopidogrel)
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Clopidogrel

Karum is an antiplatelet medicine, or blood thinner. It makes your blood flow through your veins more easily. This means that your blood will be less likely to make a dangerous blood clot. Taking Karum helps prevent blood clots if you have an increased risk of having them. Your risk is higher if you have or have had: a heart attack; unstable angina; a stroke or "mini-stroke" (transient ischaemic attack or TIA); peripheral arterial disease; an operation on your heart or blood vessels, such as a coronary stent insertion. Karum comes as tablets and is only available on prescription.

Other names for this medication:
Clopidogrel, Plavix, Anclog, Anlet, Antiplar, Artevil, Clavix, Clopicard, Clopilet, Clopivas, Deplatt, Diloxol, Duoplavin, Expansia, Farcet, Globel, Grepid, Iscover, Karum, Klopidogrel, Nabratin, Narutis, Nefazan, Noklot, Pidocar, Pidogrel, Pladex, Plagerine, Planor, Tisten, Troken, Trombex, Vaclo, Zyllt,

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Due to the increasing consumption pattern, it has been cultivated and marketed intensively since the 1970s. Osteoblastoma is a slow-growing, locally destructive benign bone neoplasm, rarely occurring in the laryngeal cartilage. Targeting the tumor stroma may be important to reduce the rate of HNSCC metastasis. Human embryonic stem cells (hESC) can differentiate into a variety of specialized cell types, and they constitute a useful model system to study embryonic development in vitro.

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In such cases, the analysis is further complicated by uncertainty about which chemical species actually stimulate. For this, 406 subjects (153 controls, 67 inactive HBV-carriers, 65 patients with chronic-active HBV, 62 HBV-cirrhotics, and 59 subjects with HBV-HCC) were enrolled in the study. In rare cases of obstruction of IVC, ablation of CTI can be performed only through the superior vena cava (SVC) access. Extraction methods determine the antioxidant capacity and induction of quinone reductase by soy products in vitro. To explore interactions among personal, cancer, aging, and symptom variables relative to physical function (PF) in older adult breast cancer survivors to better identify vulnerable subgroups.

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nidulans signalling mutants revealed that NFAP activates the cAMP/protein kinase A pathway via G-protein signalling which leads to apoptosis and inhibition of polar growth. Epidermal growth factor increases inhibin synthesis by isolated segments of rat seminiferous tubules. A peculiar aspect, additionally detected, was relating to the capability of foetal intestinal mucosa to absorb large-molecular substances, such as inulin. Multidetector computed tomographic esophagography was found to identify the presence and grade the size of esophageal varices.

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Pre-pleural lavage cytology is of less use in clinical practice. To achieve this, several hydrolytic enzymes of snake venom have evolved to interfere in various physiological processes, which are well defined. S-100B determination has been shown to be clinically useful in the management of melanoma patients. Interventional, prospective study involving seven patients taking oral isotretinoin to treat acne and with atrophic acne scars on the face. Fate of modular cardiac tissue constructs in a syngeneic rat model.

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Age-related brain atrophy and mental deterioration--a study with computed tomography. Further experiments using a B-Myb dominant-negative protein suggested that transcriptional activation of genes regulated through Myb DNA-binding sequences was required for cell proliferation. We measured pulmonary arterial pressure (Ppa), left atrial pressure (Pla), aortic pressure (Psa), cardiac output (CO), oncotic pressures of both plasma (IImv) and lung lymph (IIpmv), lung lymph flow rate (Qlym), and lymph-to-plasma ratio of total protein (L/P). Further analysis revealed that NIPP1 specifically recognizes hyperphosphorylated Sap155 thorough its Forkhead-associated domain and dissociates from Sap155 after dephosphorylation by associated PP1.

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The role of IgE-mediated hypersensitivity in otitis media with effusion. (1)H NMR data support the intermediacy of a cyclopropenium intermediate, and the reaction is demonstrated to proceed primarily via the S(N)2 mechanism for 1-phenylethanol. This review discusses techniques for univariate, adaptation, and multivoxel analysis, and how they have been used to answer questions about content specificity in different regions of the brain, how this content is organized, and how representations are shaped by and contribute to cognitive processes. This is a variety of granulosa cell tumor that is observed almost always in children and has a distinctive appearance. We hypothesized that maturation ameloblasts express SLC26A4 to neutralize acidification of enamel fluid in forming enamel.

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Biochemical insights into the function of phage G1 gp67 in Staphylococcus aureus. Our report highlights the imperative need for immediate haematological diagnosis despite the non-specific presentation. In this short review, we discuss the pathology, incidence, clinical aspects, imaging findings, significance and future questions that need to be addressed concerning this important sign.

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Furthermore, we achieved an increase of the maximal flow rate from 13.4 to 22.5 ml s-1. After radiofrequency catheter ablation of the anterograde conducting pathway, orthodromic reciprocating tachycardia, which previously could not be induced despite an aggressive protocol, was easily induced. Characterization of a factor from human ovarian follicular fluid which stimulates Leydig cell testosterone production.

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They are considered responsible for a range of diseases in AIDS patients including retinitis, gastrointestinal disease, pneumonitis and, less frequently, encephalitis. We demonstrate how to dissect and culture cortical explants on porous polycarbonate membranes in order to grow developing cortical tissue with reduced volumes of media or CSF. Microbial reductive dechlorination of TCE with nano iron serving as electron donor Changes in the vasoreactivity of PCAs to central visual stimulation may precede marked central visual field loss.

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A Prospective, Randomized, Masked, and Placebo-Controlled Efficacy Study of Intraarticular Allogeneic Adipose Stem Cells for the Treatment of Osteoarthritis in Dogs. The function and underlying mechanism of endothelial miRNAs have not been fully defined. These distinct lower extremity alignment factors were consistent across side and sex. Surfactant protein D (SP-D) is involved in the innate immunity within the lung and may have important roles in modulating the inflammatory process of asthma.

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This study was conducted to determine the ultrastructural distribution of the VC1.1 antigen and to identify the particular subclasses of cortical neurons that were labeled. Both approaches count matches within a tolerance r for templates of length m consecutive observations. Furthermore, we constructed a replication-defective recombinant adenovirus encoding the core-E1-E2 genes of HCV (Ad.CMV.HCV) and examined immunogenicity of the virus in mice.

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Plant growth and rosette mineral contents strongly decreased in WDC compared with OWC. In Western analysis, PS-7.6 mAb identified not only the 22.5 kDa recombinant pGH, but also the native pGH in swine pituitary gland. Sound knowledge of fingertip anatomy and of the potential for long-term morbidity are essential in formulating an organized approach to fingertip injuries.

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Hardness and wear resistance of carbon nanotube reinforced aluminum-copper matrix composites. The integration approach enables the public sector PHC system to test more patients for HIV, place more patients on ART more quickly and efficiently, reduce loss-to-follow-up, and achieve greater geographic HIV care coverage compared to the vertical model.

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Onychomycosis is usually caused by dermatophytes, although also other filamentous and yeast-like fungi are associated with nail invasion. Routine Doppler evaluation, after CT has already been performed, is not required in Wilms tumor. Re: Critical assessment of the European Association of Urology guideline indications for pelvic lymph node dissection at radical prostatectomy. In addition, the fluctuation of STEAP4 mRNA was analysed before and after treatment with infliximab in 40 patients with RA. Substitution of 3H by methyl or n-decyl increases the lipophilic character and may facilitate diffusion across cell membranes.

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In this study, we identified the presence of unknown ssDNA binding proteins specifically bound to MOR ssPPy element in the mouse brain, implicating the physiological significance of these proteins. Modelled venous insufficiency of the hind limbs of cats (ligation of the posterior vena cava for 4-6 weeks) led to structural reorganization of the venous walls of the gastrocnemius muscle, which was manifested by a sharp increase of stretchability of the venous bed of the muscle if the activity of the smooth muscles was removed by papaverine, and by significant loss of the sensitivity of the smooth muscles of the intramuscular veins to noradrenaline as regards function.

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A cross-sectional statewide survey of family members of persons who died from lung cancer was conducted as part of the larger study on the Assessment of Cancer CarE and SatiSfaction in Wisconsin. Due to some ambiguity in the results as to the level of processing of each hemisphere, an additional experiment was conducted which aimed to resolve this difficulty through a modification to the scrambled sentence condition. Lingual vibrotactile screening: an investigation of normal sensitivity based on multiple threshold determinations. Seven years experience of pancreaticoduodenectomy at Sawanpracharak Hospital. Opiate-receptor antagonist nalmefene improves neurological recovery after traumatic spinal cord injury in rats through a central mechanism.

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Simulations and experiments in urban areas have demonstrated the validity and efficacy of the new constraint in aiding GNSS attitude determinations. Dispositions and residue depletion of enrofloxacin and its metabolite ciprofloxacin in muscle tissue of giant freshwater prawns (Macrobrachium rosenbergii).

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Nutrition labelling, environment, sustainability--drowning in labels. It will be discussed which strategies were successful and what the most important results have been in the first decade of Solvias. This may potentiate the development of specific somatic cancers. It is a quick and safe technique with minimal morbidity and a low complication rate.

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In addition, rosiglitazone increased IkappaBalpha protein expression only in zinc adequate mice. An HPLC method was established to assess the levels of safrole and methyleugenol in five batches of Asari radix et rhizoma and two TCM formulae containing this herbal drug as an ingredient. In 34 patients with primary or metastatic tumors of the cervical spine over a ten-year period, the presenting symptom was neck pain.

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Among those childhood cancer survivors who do attend a Survivor clinic, a majority are in need of continued education about their specific cancer treatments, recommended follow-up practices, and risk of late effects. The incoherent inelastic neutron scattering spectrum of parabanic acid was measured and simulated using solid-state density functional theory (DFT). The larger interindividual variability of tacrolimus bioavailability for oral formulations appears to be due to the effects of the CYP3A5 polymorphism and the tacrolimus oral formulation. Their protein oxidation, DNA damage, lipid peroxidation and antioxidants, vitamin C, vitamin E, glutathione (GSH), and antioxidative enzymes in serum were detected. Resolving the mystery of aqueous solutions of tertiary butyl alcohol.

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Bendamustin administration is not connected with a distinct proteinuria. Inner ear cell therapy for hereditary deafness has been studied using some laboratory animals and multipotent stem cells, although the successful reports for the hearing recovery accompanied with supplementation of the normal functional cells followed by tissue repair and recovery of the cellular/molecular functions have been still few. Predictors of 5-year mortality in pulmonary Mycobacterium avium-intracellulare complex disease. Cross-reactivity was observed, however, with antisera to bovine and ovine peptide sequences 102 to 117, thus stressing the importance of the location of the amino acid substitution in synthetic peptides used for immunization. jejuni, only the qPCR assay accurately measured 2-fold changes in cell concentrations in water samples, whereas concentrations of E.

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We asked whether the mobile-bearing knee prostheses could offer clinical and radiographic advantages over the fixed-bearing knee prostheses. Older females and spouses still play an important role in providing family care for those with dementia. Hypercoagulability in patients with cancer is related to malignancy itself and its treatment.

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The ability to isolate rapidly a purified population of microglia from adult brain provides a means for investigating mechanisms of activation and differentiation of tissue macrophages, which could elucidate their role in inflammation of the central nervous system. Future work should clarify these areas as well as provide a better understanding of our available therapeutic options. However, in agreement with the microarray data, expression of atxA, as measured using an atxA-lacZ transcriptional fusion and by assaying atxA mRNA, was not significantly affected in the codY mutant. Cardiac troponins are the most sensitive and specific markers of myocardial injury. These results suggest an important role for ERK2 in the translational control of MBP, a myelin protein that appears critical for ensuring the timely generation of new myelin sheaths following demyelinating injury in the adult CNS.

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Furthermore, spatial positions of regenerated branches seemed to be regulated by the apical region, which was assumed to generate inhibitory effects for lateral branch regeneration. Our results may provide evidence for application of LV-shRNA targeting HR-HPV key oncogenes, as a new treatment strategy, in cervical and other HPV-associated cancer therapy.

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Are different subtypes of autism spectrum disorders associated with different factors? The average patient age was 56 years, and almost all patients presented with palsy of the cranial VII and VIII nerves. They combine elaborate patterns of imprinting, alternative splicing, and antisense transcription with tissue- and developmental stage-specific expression. Adequate diagnosis, therapeutic procedures, and prognosis are discussed, together with a review of literature. Low-dose heparin versus full-dose heparin with high-dose aprotinin during cardiopulmonary bypass.

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The enlargement of the left ventricle was found to be proportionate, as the ratio of diastolic diameter to wall thickness showed no change. EDA(-/-) and wild-type (WT) mice were sensitized and exposed to inhaled ovalbumin (OVA) or saline for 5 weeks. Hif-1alpha expression was observed specifically in mature and hypertrophic chondrocytes, and Hif-1alpha-positivity, level of Vegf expression, and tartrate-resistant acid phosphatase (TRAP)-positive cell numbers all increased in the same manner. The results reveals that the enrichment factor, metal pollution index and geo-accumulation index of these estuarine sediments were predominantly polluted by Cd, As, Zn, Hg and Pb.

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There is still unmet medical need in the therapy of severe organ manifestations of patients with systemic lupus erythematosus (SLE). The general practitioner therefore, plays a crucial role in the direct management of asthma and in assisting patients to optimally self manage their asthma. Coarse fractionated radiation therapy for pituitary tumours in cats: a retrospective study of 12 cases. Microwave-assisted nonaqueous sol-gel deposition of different spinel ferrites and barium titanate perovskite thin films. Atropine depressed bicarbonate responses to low loads (3, 6, and 12 mmol.h-1) of HCl but had no significant effect on responses to high loads (12, 24, and 48 mmol.h-1).

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Fluid overload and mortality are associated with acute kidney injury in sick near-term/term neonate. E-cadherin expression: a diagnostic utility for differentiating breast carcinomas with ductal and lobular morphologies. We anticipate that the definition of malnutrition will continue to evolve with improved understanding of the processes that lead to and complicate the treatment of this condition. Since half of adults in sub-Saharan Africa identify themselves as Christians, addressing these issues is critical for MC efforts in this region. Altered innate immune response of plasmacytoid dendritic cells in multiple sclerosis.

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For electrically connected cylinders in a helical magnetic field, hydrodynamic instability is possible at any sufficiently strong differential rotation. A rat model of neonatal candidiasis demonstrates the importance of lipases as virulence factors for Candida albicans and Candida parapsilosis. Maxillary molar distalization therapy in adult patients: a multicentre study.

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Novel self-healing protective coatings with nanocontainers of corrosion inhibitors open new opportunities for long-term anticorrosion protection of different metallic materials. Thus, Sp1 and our previously described nuclear respiratory factors 1 and 2 are the three key regulators of all 13 COX subunit genes in neurons.

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CD spectroscopy of the peptide in dodecyl phosphocholine micelles showed an increase in the ordered structure of the peptide. As demonstrated by steady state fluorescence spectroscopy and flash photolysis, mesotetra (p-sulfonatophenyl)porphyrin (TPPS) binds to lens proteins. A total of 225 patients of severe brain trauma were admitted to the accident and emergency unit of Neurosurgery and after initial resuscitation a CT brain was performed. Phylogeny and quaternary history of the European montane/alpine endemic Soldanella (Primulaceae) based on ITS and AFLP variation.

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Alcohol-induced oxidative/nitrosative stress alters brain mitochondrial membrane properties. The study population consisted of 184 subjects: 44 patients with endometrial cancer and 140 controls without cancer. The novel measure used to trace the interest in particular NPS could be a useful tool to follow trends in substance use in almost real-time.

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A new dual-chamber defibrillation system: duration, frequency and circadian variation of recurrent supraventricular tachyarrhythmias Results show vast differences in demand for care by ethnic, racial, and gender groups with identical insurance coverage. Biometric-genetic analysis of genotype dissimilarity: the model and parameters We establish a necessary and sufficient condition for the two approaches to yield identical estimates, and some sufficient conditions for the superiority of one approach over the other, under the mean squared error criterion.

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Analysis of ROP signaling in the leaf epidermis of mutant tomato with low-energy ion beam. In the tumour centre itself vessels are found with fenestrations and even true endothelial gaps. We found that CuD rats had higher liver and spleen Fpn levels and markedly lower hepatic hepcidin mRNA expression than did copper-adequate (CuA) rats. Pentavalent and tetravalent uranium selenides, Tl3Cu4USe6 and Tl2Ag2USe4: syntheses, characterization, and structural comparison to other layered actinide chalcogenide compounds.

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Period analysis for more up-to-date graft and patient survival estimates in transplantation: an evaluation using united network for organ sharing data. Patients with gastric cancer and liver metastases are believed not to benefit from gastric resection. Gastrostomy feeding in children is well established for nutritional support. Elucidating the molecular changes that arise during neural differentiation and fate specification is crucial for building accurate in vitro models of neurodegenerative diseases using human embryonic stem cells (hESCs). The effect of human recombinant interleukin-1 beta (hrIL-1 beta) on tumor growth was studied in eight glioma cell lines.

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When IgM to lipopolysaccharide was given to newborn rats in conjunction with IgM monoclonal antibody to the group B meningococcal polysaccharide, the protective effect was significantly greater than that of either antibody alone. They have also revealed the crucial importance of controlled cell migration not only for patterning the system, but also for determining polarity (and therefore directional sensitivity) of the mechanosensory hair cells. This study hypothesized that arterial spin labeling (ASL) magnetic resonance (MR) imaging at 3-T would be a reliable noncontrast technique for measuring peak exercise calf muscle blood flow in both healthy volunteers and patients with peripheral arterial disease (PAD) and will discriminate between these groups.

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A systematic review was conducted, with comprehensive searches identifying six randomised controlled trials (RCTs) and eight nonrandomised comparative studies. A working group of national stakeholder representatives and external reviewers commented on and contributed to successive drafts of the report. An ischaemic segmental stenosis of the small bowel is a rare lesion, but can lead to acute or subacute obstructive symptoms.

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Therefore, it is inappropriate to generalize IIT for all critically ill patients, even though it significantly improved blood glucose control. Changes in inner plexiform layer thickness following neonatal visual cortical ablation in cats. Environmental monitoring of Aspergillus spores in the air of postoperative units is mandatory, even when these units receive nonimmunocompromised patients undergoing major surgery. Sexual activity provoked a nalox information literacy hypertrophy and functional hyperplasia in all lobes, but D1 and acid phosphatase activity increased only in the ventral lobe. Totally 26 patients, younger than 14 years of age, who had a diagnosis of pulmonary Mycobacterium tuberculosis (TB), underwent both chest radiographs and computed tomography (CT), which were retrospectively reviewed and compared with those of 20 patients with community-acquired bacterial pneumonia (CABP).

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Radiofrequency ablation versus hepatic resection for hepatocellular carcinoma within the Milan criteria--a comparative study. However, whether Ig expression norfloxacin metronidazole syrup for cats in nonlymphoid cells is limited to epithelial cells is unclear. This increased responsibility is in addition to preventive services, health maintenance, and routine care of acute and chronic conditions.

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