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Simarc (Warfarin)

Simarc produces an anticoagulant effect by interfering with the cyclic interconversion of vitamin K and its 2,3 epoxide (vitamin K epoxide). Vitamin K is a cofactor for the carboxylation of glutamate residues to γ-carboxyglutamates (Gla) on the N-terminal regions of vitamin K–dependent proteins. These proteins, which include the coagulation factors II, VII, IX, and X, require γ-carboxylation by vitamin K for biological activity. By inhibiting the vitamin K conversion cycle, Simarc induces hepatic production of partially decarboxylated proteins with reduced coagulant activity.

Other names for this medication:
Warfarin, Coumadin, Aldocumar, Circuvit, Coumadine, Hemeran, Jantoven, Kovar, Marevan, Marivarin, Martefarin, Orfarin, Panwarfin, Simarc, Warafin, Warfarina, Warfarine, Warfin, Warin, Warlin,

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