Simarc produces an anticoagulant effect by interfering with the cyclic interconversion of vitamin K and its 2,3 epoxide (vitamin K epoxide). Vitamin K is a cofactor for the carboxylation of glutamate residues to γ-carboxyglutamates (Gla) on the N-terminal regions of vitamin K–dependent proteins. These proteins, which include the coagulation factors II, VII, IX, and X, require γ-carboxylation by vitamin K for biological activity. By inhibiting the vitamin K conversion cycle, Simarc induces hepatic production of partially decarboxylated proteins with reduced coagulant activity.
Other names for this medication:
Warfarin,
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Kovar,
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Martefarin,
Orfarin,
Panwarfin,
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Warafin,
Warfarina,
Warfarine,
Warfin,
Warin,
Warlin,
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