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Leonard Hayflick awarded 1991 Sandoz Prize by the International Association of Gerontology. Diagnosis and treatment control of bleeding colorectal angiodysplasias by endoscopic Doppler sonography: a preliminary study. Baker), a native plant of Southeast Asia, is traditionally used to enhance male sexual function.

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Dissecting motivational circuitry to understand substance abuse. Based on data obtained from a high-speed video recorder, a phenomenological description is proposed for the evolution of intense pressure waves and cavitation in the target liquids. Sulcus implantation of the secondary piggyback ICL to correct unilateral pseudophakic myopic refractive error in children was safe, efficient, predictable and well tolerated in management of anisometropic amblyopia in all eyes. Tissue biopsies for histological analysis were periodically performed and analyzed for wound healing progression, epidermal thickness, and extracellular matrix formation. Differentiation of proliferating prechondroblasts into hypertrophied chondrocytes continued under organ culture conditions.

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Sports Cardiology: Comprehensive Clinical Care for Athletes and Highly Active Individuals. Nonetheless, combined treatments and treatments focused on newly discovered proangiogenic and prolymphangiogenic factors give hope that more prominent therapeutic effects might be achieved in the future. Through a grounded theory approach we compared results from qualitative interviews and open Internet discussions, and found that women struggled with credibility and that their claims for sick leave or medical care were commonly disregarded.

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Coils with radius larger than 3.5 mm indicate that macro-bending induced radiation loss is negligible up to 2400nm. Furthermore, we also present evidence that the copy number of isoacceptor tRNAs (those having a different anticodon but charge the same amino acid) is correlated with codon usage patterns of highly expressed genes in Nasonia. Third party software can be used to generate 3-dimensional models that provide useful information about shape, size, and location of sublingual and submandibular concavities prior to implant placement. Using ideas borrowed from density functional theory, we calculate the approximate paraxial diffracted intensity derivative from the measured diffracted intensity distribution and use it to solve the Transport of Intensity Equation (TIE) for the phase of the wave at the detector plane. Methods and the degree of modulation of UV-sensitivity of proteins of the mentioned systems have been discussed.

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Aggregated Sertoli cells were present in dome-type protrusions as a major component, and spermatogenesis associated with active mitoses of spermatogonia was induced with development of protrusions. Effect of prior stimulant treatment for attention-deficit/hyperactivity disorder on subsequent risk for cigarette smoking and alcohol and drug use disorders in adolescents.

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Soft-tissue maintenance is crucial to the long-term success of an implant-retained prosthesis. Speciation in the deep sea: multi-locus analysis of divergence and gene flow between two hybridizing species of hydrothermal vent mussels. 13 studies concern patients after myocardial infarction and one a cerebral hemorrhage patient. Prognostic factors for post-recurrence survival in patients with completely resected Stage I non-small-cell lung cancer.

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The laser consists of a liquid cooled, copper waveguide which serves to both guide the pump light and to provide a thermally conductive surface near the gain volume to remove heat. Shaping functional vocal language is difficult when an individual has not yet acquired an echoic repertoire and does not emit sufficient phonemes (i.e., speech sounds) for shaping. It may have a role in the prevention and treatment of human breast cancer.

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We investigated the effect of ketogenic diet (KD) on clusterin accumulation in the kainic acid (KA)-induced seizure model. Physiologically-based pharmacokinetic models in risk and exposure assessment.

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The isolation and construction of a complete human p53 cDNA and subsequent expression in monkey cells is described. We investigated the role and turn around time of rapid staining and immediate interpretation of fine-needle aspiration cytology (FNAC) for women with palpable breast lesions. Fluid dynamics is described by a Newton-like equation with a variable mass, but without the mass derivative term. Our results thus indicate a role of the PPC in the flexibility in spatial behaviors guided by visual orientation cues. It is recommended that other bioproducts should be subject to similar rigorous tests prior to being taken up by the water industry for field trials/application.

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The antitumor effect was reduced in immunosuppressed mice given anti-asialo GM1 serum and in athymic mice, but not in mice irradiated with X ray. Many of these studies resulted in the leads that were later developed as drugs. Calcitonin therapy for the first 6 months after OLT is unable to prevent or reduce accelerated bone loss or spontaneous fractures which occur in the first posttransplant year. These results imply that run length is determined not only by the load, but also by the concentration and type of nucleotides present, and therefore that the biochemical cycles of the two motor domains of the Eg5 dimer are coordinated to promote processive stepping. Design and challenges of the Randomized Evaluation of Normal versus Augmented Level Replacement Therapy (RENAL) Trial: high-dose versus standard-dose hemofiltration in acute renal failure.

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Neural expression of the transcription factor THAP1 during development in rat. Compared with the conventional electrochemical methods, high efficiency and fast degradation rate were markedly displayed due to the co-action of thermo- and electrochemical effects and the switch of the indirect electrochemical oxidation to the direct one for oxidation of nitrobenzene. Relationships between milk levels of hormones and growth or puberty of offspring in mice.

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The Royal College of Physicians (RCP) organised an inaugural 1-day conference, the aim of which was to look into some of the key issues that junior doctors need to address when beginning their careers. DNA binding and transcriptional activation by a PDX1.PBX1b.MEIS2b trimer and cooperation with a pancreas-specific basic helix-loop-helix complex. The clinical examination of the anterior cruciate ligament was unremarkable, with no signs of deficiency or rupture.

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A closer examination of how the changes in the primary amino acid sequence of Neisseria porin molecules correlate with these observed biophysical changes has been impeded by the inability to easily manipulate the cloned porin genes by modern molecular techniques and then obtain enough of the expressed modified porin protein to purify and use in these biophysical functional assays. The accuracy of SPECT brain activation images: propagation of registration errors. In this paper we apply the MS-ARX model to cortical electroencephalograms and subthalamic local field potentials simultaneously recorded from anesthetized rodent brains. Over the past few decades, lasers have gained increasing use in medicine. The PDGF-induced cascade was studied with and without GLA to determine the level of regulation that induced the observed suppression.

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All records from our institution of fetuses with HLHS/IAS that underwent prenatal atrial septal stent placement were reviewed, including operative notes and echocardiograms. These technologies include ablation catheters designed to electrically isolate the pulmonary veins with improved safety, efficacy, and speed, catheters designed to deliver radiofrequency energy with improved precision, robotic systems to address the technological demands of the procedure, improved imaging and electrical mapping systems, and MRI-guided ablation strategies.

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To evaluate the safety and 1-year outcome of the intraocular lens (IOL) scaffold technique in eyes with soft to moderate nuclear remnants after intraoperative posterior capsule rupture (PCR). Lifestyle factors and prostate-specific antigen (PSA) testing in UK Biobank: Implications for epidemiological research. The explanation also covers formation of corpus callosum, positions of visual and olfactory cortices, positions of auditory and vestibular centers and the position of basal ganglia, superior colliculus and the cerebellar nuclei. The effect of the antagonists on the PAF-induced vasopermeability was also assayed. Guidelines for interpreting the validity of scores on the Recognition Memory Test for use in forensic settings.

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Our results demonstrate that adaptive evolution has occurred independently multiple times in garter snakes via the de novo acquisition of beneficial mutations. These results suggest that early in development, labels are no more than features, but that they may become category markers in the course of development.

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Home health agencies are keenly aware of quality measures and related reimbursement effects. ANGPTL4 expression induced by butyrate and rosiglitazone in human intestinal epithelial cells utilizes independent pathways. Our data demonstrate that overexpression of Cu/Zn-SOD and/or catalase leads to an 18- to 20-fold increase in the expression of AhR protein in MAECs. These results demonstrate the ease with which the NEQ of CBCT can be modified and thus optimized for specific tasks and show how such analysis can be used to improve image quality. It is, therefore, important to minimize accommodation to obtain a measure of hyperopia as accurate as possible.

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Exposure of human umbilical cord endothelial cells (HUVECs) to vascular endothelial growth factor (VEGF) significantly enhanced tube formation. In one instance DNA was isolated from cell lines generated from sequential biopsies taken from the same patient at different times of rejection.

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ROS production, mitochondrial alteration, and subsequent apoptotic cell death in costunolide-treated cells were blocked by the antioxidant N-acetylcystein (NAC). The main complications of chronic pancreatitis are pancreatic pseudocysts and pancreatic carcinoma. The value of injection of the involved carpometacarpal (CMC) joint with local anesthetic in predicting improvement from the surgery was also studied. Cytokeratin polypeptide expression during the histogenesis of guinea pig submandibular salivary gland.

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The rest of the chromosome and the other two pairs fluoresced orange-red. Measurement of the acetabular centre of rotation showed a mean lateralization of 1.1mm. Coma associated with microscopy-diagnosed Plasmodium vivax: a prospective study in Papua, Indonesia.

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To date, very little is known about the normal development trajectory of visual texture segregation, or how it is affected by preterm birth. Significant differences in response to psychotropic drugs are observed in various ethnic and cultural groups. Interestingly, the CsR and SwR cells were each pleiotropically resistant to castanospermine, swainsonine, and deoxymannojirimycin, an inhibitor of mannosidase I. Rifaprim (rifampicin plus trimethoprim): pharmacokinetics and effects on the normal flora of man. Reinfusion of IIB also promoted a more rapid restoration of cellularity of lymphoid organs with cAMP predominating therein.

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Fifty-six composite resin bonded Ni-Cr disks were prepared and tested to tensile failure with the Kemper-Kilian device. Acute vestibular syndrome (AVS) is often due to vestibular neuritis but can result from vertebrobasilar strokes. Most likely this is due to a lack of sensitivity of OspC immunoblots that are unable to detect rare OspC variants.

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NF-E2 can alter histone modifications, and NF-E2 transgenic mice show hypoacetylation of histone H3. We have identified a novel carbonic anhydrase gene (ca19) beyond the single carbonic anhydrase gene (ca18) that was known previously. An hybridoma cell line cultivated in flasks has been used as a model to study the loss of cell viability in high density cell cultures. A contiguous fibrolipoma can sometimes be seen extending from the subcutaneous portion of the tail into the inferior spinal cord, resulting in tethered cord syndrome.

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Further development will be required for its suitability for correlating in vitro and in vivo outcomes. Supramolecular fabrication of multilevel graphene-based gas sensors with high NO2 sensibility. Both pT stage and N stage appear to be the most important factors determining survival for patients with completely resected esophageal carcinoma.

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Seventeen tumours contained integrated HPV-16 and in 13 of these there was evidence of disruption within the E1-E2 open reading frames (ORFs). These developments mean that the effective treatment of early breast cancer must entail removal of the tumour, achieve local control of disease and include axillary node dissection. In vitro 3H-thymidine incorporation per adrenal was markedly higher in monoadrenalectomised than in sham-operated aldosterone-treated males while the opposite was true for female hamsters. Finally, in vitro binding study on BT4C cells expressing lodavin fusion protein, bearing the extracellular avidin moiety, showed that such biotin-covered PLNP could successfully be targeted to malignant glioma cells through a specific biotin-avidin interaction. These results indicate that microtubule-stabilizing drugs are effective at reducing disease but require a prolonged exposure to paclitaxel in vivo to alter proliferation in the myeloid and lymphoid cell compartments.

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Awareness of this pathology may be useful because its evolution is usually good with a non-steroidal anti-inflammatory drug or a local steroid infiltration after exclusion of an infectious origin of the effusion. The aim of this research was to assess the effects of a series of four training courses comprised of 13 synchronous videoconferences on the implementation of cognitive services in Spanish community pharmacies. At the same time a resurgence of expert-led prevention strategies could be observed. In 6 patients with drug-resistant focal epilepsy, standard video-EEG was performed to identify clinical seizure semeiology, and high-density EEG, ASL and FDG-PET to non-invasively localize the epileptic focus.

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The human interferon-inducible IFI16 protein, an innate immune sensor of intracellular DNA, was recently demonstrated to act as a restriction factor for human cytomegalovirus (HCMV) and herpes simplex virus 1 (HSV-1) infection by inhibiting both viral-DNA replication and transcription. We show how the ring-polymer molecular dynamics method can be adapted to calculate approximate Kubo-transformed flux-side correlation functions, and hence rate coefficients for condensed phase reactions. The internal pilot study design allows for modifying the sample size during an ongoing study based on a blinded estimate of the variance thus maintaining the trial integrity. Changes in the sensitivity of lymphocytes to serotonin in patients with rectal cancer It is associated with precordial pain, ST segment elevation, absence of coronary occlusion and reversible deformation of the left ventricle due to anteroapical dyskinesia that is reminiscent of a Japanese art of fishing octopuses (tako-tsubo).

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Trafficking of plant vacuolar invertases: from a membrane-anchored to a soluble status. Engineering source controls can reduce worker exposure to noise. Thus by monitoring the interference between the noises one can understand the mechanism of a chemical reaction.

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Previous work has shown that distractors present in a visual search display attract attention when they match objects kept in visual working memory. To evaluate whether the a-wave of the dark adapted flash electroretinogram (ERG) is affected by glaucomatous damage. We delineate molecular phylogeny of five distinct gene superfamilies coding for essential heme oxidoreductases in Chaetomia and from the transcription analysis the role of this antioxidant enzymatic armory for the survival of a peculiar soil ascomycete in various harsh environments. An investigation into the radiation dose associated with different imaging systems for chest radiology. Clinical and microbiologic findings in lambs inoculated with Pasteurella haemolytica after infection with ovine adenovirus type 6.

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We performed experiments to test the potential of MDCs to survive and differentiate within the GI smooth muscle in order to gain further knowledge on the biology of skeletal muscle transplantation in GI smooth muscle sphincters as well as to test the safety and feasibility of endoscopic injection of MDCs in a large animal model. The purpose of this study was to describe the acceptability of bariatric referrals when offered by gynecologic oncologists to women with a history of complex atypical hyperplasia or early-stage endometrial cancer and to detail compliance with referrals and weight loss attempts that are initiated 3 months after the referral. Review of the literature and the few cases published so far do not prove that antiplatelet agents are effective and safe and offer sufficient protection against thromboembolism. Fragmented coronoid process and osteochondritis dissecans of the medial humeral condyle. Then the color and translucency parameter (TP) of enamel slabs was measured over a black and a white background.