Topimax was first approved in the United States in 1996 for treatment of epilepsy. Topimax has gained additional approvals for treatment of migraine headaches and, in combination with phentermine, for weight loss. Topimax has high bioavailability and low binding to serum proteins. Salivary Topimax levels correlate well with plasma/serum concentrations, making saliva a viable specimen for TDM. Approximately 50% of the absorbed dose is metabolized by the liver. Inhibitors and inducers of liver drug metabolism can significantly alter the serum half-life of Topimax in adults from 20–30 h to 12 h. Children typically clear Topimax faster than adults.
Other names for this medication:
Topiramate,
Topamax,
Epitomax,
Letop,
Neutop,
Piramax,
Talopam,
Topamac,
Topictal,
Topigen,
Topilex,
Topimax,
Topina,
Topiramato,
Topirol,
Toplep,
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Long-term employment of adults with childhood-onset epilepsy: a prospective population-based study. Currently, there is neither a specific treatment nor vaccine available for chikungunya fever. No-needle anesthesia with jet injection is a new technique to deliver rapid onset of profound local anesthesia to the indications and dosage of fluconazole for oral thrush patient undergoing vasectomy.
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Sudden infant death syndrome: exposure to cigarette smoke leads to hypomethylation upstream of the growth factor independent 1 (GFI1) gene promoter. Cell death is a normal feature within the chick chorioallantoic membrane, occurring principally between days 10 and 14 of incubation. For each subject, the degree to which ribavirin dose reduction anemia signs stroke injured each of 4 descending white matter tracts (from the primary motor cortex, supplementary motor area, dorsal premotor cortex, and ventral premotor cortex, respectively) was determined. It is therefore deterministic and largely avoids the trial and error approach often applied in treatment planning of today. Experimental animal study of spinal cord injury (SCI), using a cell delivery system.
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