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Topimax (Topiramate)

Topimax was first approved in the United States in 1996 for treatment of epilepsy. Topimax has gained additional approvals for treatment of migraine headaches and, in combination with phentermine, for weight loss. Topimax has high bioavailability and low binding to serum proteins. Salivary Topimax levels correlate well with plasma/serum concentrations, making saliva a viable specimen for TDM. Approximately 50% of the absorbed dose is metabolized by the liver. Inhibitors and inducers of liver drug metabolism can significantly alter the serum half-life of Topimax in adults from 20–30 h to 12 h. Children typically clear Topimax faster than adults.

Other names for this medication:
Topiramate, Topamax, Epitomax, Letop, Neutop, Piramax, Talopam, Topamac, Topictal, Topigen, Topilex, Topimax, Topina, Topiramato, Topirol, Toplep,

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Transcultural adaptation and validation of the Korean version of the Pediatric Outcomes Data Collection Instrument (PODCI) in children and adolescents. They have a central function in lipid distribution to different membrane-bound organelles and serve not only as main reservoirs of neutral lipids such as triglycerides and cholesterol but in addition, contain structural proteins, proteins involved in lipid synthesis and transmembrane proteins. During cerebral ischemia, neurons undergo rapid alterations in dendritic structure consisting of focal swelling and spine loss. Ultrastructural analysis has been carried out on three Leishmania isolates which are proven causal agents of human cutaneous Leishmaniasis, L.

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The melanoma-associated antigen ME491 is expressed strongly during the early stages of tumor progression. Current research effort to develop new agents aims at overcoming both the primary and the acquired resistance to anti-VEGFR TKIs focusing on new molecular pathways. Wound reepithelialization was significantly delayed by bacterial biofilms.

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Effects of cocaine on pain and sensitization of pain-correlative unit of habenular nucleus neurons in rat This exploration of the criteria for technological decision making in hospitals will help decision makers consider all of the relevant aspects, leading to more structured and rational decisions. The adjuvant chemotherapy group had better Q-TWiST in the range of 5 to 6 additional months, which was statistically significant using all methods. Lymphatic mapping and sentinel node biopsy entails better staging in malignant melanoma and breast cancer and we used this technique in patients with colon cancer to possibly improve detection of lymphatic spread.

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Therefore, a follow-up with periodic serological monitoring for 1year and immunoprophylaxis or chemoprophylaxis for some of these diseases should be started. Indicative mutagens were detected especially with metabolization.

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BPD twins and co-twins performed worse than controls in the Stroop test. Identification and characterization of three previously undescribed crystal proteins from Bacillus thuringiensis subsp.

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Precise preoperative localization of prostate cancer employing 12-core needle biopsy with a tissue-marking method for effective surgical strategy. Results showed that T47D cells were found to be more sensitive to silibinin than MCF7 as observed by proliferation, clonogenic, and apoptotic assays, which was abrogated by pan-caspase inhibitor but remained unaffected by p53 inhibitor. Day-old ducklings were fed 0.1, 10, 20, or 40 ppm Se as seleno-DL-methionine or sodium selenite for 6 wk.

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Serum leptin and sOB-R concentrations in venous fasting blood samples were quantitated by immunoassay. DNA extracted from an existing population of 206 adult patients with surgery-unresponsive CRS and 196 postal-code-matched controls was used. A safe protocol for rapid desensitization in patients with cystic fibrosis and antibiotic hypersensitivity. Less is known on how smoking contributes to RA in the context of genetic variability, and what proportion of RA may be caused by smoking.

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NoR graphs can be used to analyze interactions between genotypic and environmental factors during development to produce phenotypes in inbred strains of rats and mice. To describe and synthesise previous research on factors conditioning the spontaneous reporting of adverse drug reactions among nurses. Sensitive gas chromatographic--mass spectrometric screening of acetylated benzodiazepines.

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However, this approach deserves further investigations to confirm PRP efficacy and to elucidate its mechanism of action. In addition, studies on proteinase-deficient isogenic mutants has shed light on both their housekeeping functions and potential role(s) in the pathogenicity of periodontitis. No correlation was observed between mutations leading to protein aggregation and those leading to loss of channel activity. Each patient received 500 mg of amikacin intravenously 12 h preoperatively, during surgery, and every 12 h thereafter for four more doses. The risk of second primary neoplasm in prostatic cancer patients

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The environmental availability of metals is assumed to be a key force influencing exposure levels in field soils and sediments. We synthesised an iodinatable photoaffinity probe, N epsilon-4-azidosalicylylkallidin, and used it in an attempt to identify candidate bradykinin receptors on the NG108-15 neuroblastoma X glioma hybrid cell line. This may be particularly accurate to do in the heterogeneous non-LS group of patients.

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Internalized biotin-p53 partially colocalized with early endosomes, as confirmed by confocal microscopy. Newer neuropeptides related with anorexia and oxygenia have been found in the hypothalamus. Exploring rock fissures: does a specialized root morphology explain endemism on granite outcrops? One possibility is that a surfactant, a surface-active polymer, a polyelectrolyte or their mixture are added to a liquid (usually water).

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Accordingly, northern blot analysis showed decreased levels of mRNA encoding for IL-1 beta, IL-6, IL-8 and TNF alpha in PUVA-treated PBMC. The prepared compounds were assayed in vitro for antimicrobial activity and found practically inactive.

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Cotransfection of replicating but non-packaging AAV helper constructs in the presence of adenovirus (Ad) produces a high level of Rep and Cap proteins. This study suggests that resistin is involved in radiographic changes in hand OA, and that adipokines contribute to pathogenesis in radiographic outcomes in hand OA. A novel technique for endoscopic reanastomosis in a patient with a completely strictured colorectal anastomosis.

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Occupational allergy caused by marigold (Tagetes erecta) flour inhalation. Further analysis demonstrated that these Mabs reacted only with rat (13/23 astrocytomas, 2/4 gliomas, 1/11 neurinomas) or mouse (2/10 astrocytomas) neurogenic tumor cells induced by both viral and chemical agents. To explore attitudes toward hypothetical vaginal microbicides and willingness to use them among female sex workers (FSWs) in a district of Beijing, China, and to identify factors likely to affect acceptability and use of microbicides for HIV prevention among this population.

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Following a comprehensive history and physical exam estimation of measles antibody titer by neutralization testing was carried out on 10 infants prior to vaccination and on 8 infants prior to as well as one month following vaccination against measles utilizing the Edmondston-Zagreb strain. Carcinogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the Syrian golden hamster. Simultaneous measurement of acetylcholine and choline in brain by pyrolysis-gas chromatography-mass spectrometry. Isolated mtDNA was extremely sensitive to BLM such that 10 nM BLM caused loss of intact form.

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Impact of the double expression of MYC and BCL2 on outcomes of localized primary gastric diffuse large B-cell lymphoma patients in the rituximab era. A personal invitation to contribute to the development of a new classification of acute pancreatitis severity was sent to all surgeons, gastroenterologists, internists, intensivists and radiologists currently active in the field of clinical acute pancreatitis. In the remaining three patients, who ranged from 36-38 weeks of pregnancy at diagnosis, neurosurgical intervention was deferred until after delivery. Modulatory effects of garlic, ginger, turmeric and their mixture on hyperglycaemia, dyslipidaemia and oxidative stress in streptozotocin-nicotinamide diabetic rats.

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The conduct of studies and dissemination of findings are guided by input from Stakeholders in the ESRD community. Male germ cells utilise small RNAs to control the complex and specialised process of sperm production.

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Thus quantitative changes in TGF-alpha and EGFR levels in the microenvironment of oral tumours have been observed in vivo. In this model system designed to make nonspecific PBMC adhesion readily apparent, we demonstrate LNCaP enrichment from PBMCs by precisely tuning the applied AC electric field frequency to enhance immunocapture of LNCaPs and reduce nonspecific adhesion of PBMCs with positive and negative DEP, respectively.

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Architecture of the Atg17 complex as a scaffold for autophagosome biogenesis. Concurrent and predictive validities of the Bayley Motor Scale and the Peabody Developmental Motor Scales. Transplanted Peripheral Blood Stem Cells Mobilized by Granulocyte Colony-Stimulating Factor Promoted Hindlimb Functional Recovery After Spinal Cord Injury in Mice. Knowledge space theory, formal concept analysis, and computerized psychological assessment.

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The purpose of this review is to assess the potential role of p53 in clinical oncology. Our reasons are, first, that their study was constrained in ways that restrict the generalisability of their results, but second, and of far greater significance, their statistical approach was entirely unsuited to their data and their results misled them to erroneous conclusions.

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A comparison of HIV-1 integrase inhibition by aqueous and methanol extracts of Chinese medicinal herbs. While some sensory descriptors commonly reported by adults were used, descriptions of NP pattern and impact were also integral to their narratives. coli strains apparently underwent an ancestral loss of Trg and Tap chemoreceptors, which sense sugars, dipeptides, and pyrimidines. The objective of this trial was to validate a predictive model to assess the risk for EOC in women with a pelvic mass. PubMed, CINAHL, EMBASE, the Cochrane Library, and PEDro were searched for relevant RCTs up to October 1, 2011.

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Gel shift assays revealed that YhcR binds to the promoter regions of the lac and opuC operons. Testosterone-estradiol binding globulin (TeBG) in hirsute patients treated with cyproterone acetate (CPA) and percutaneous estradiol. Curcumin, the bioactive component of curry spice turmeric, and its related structures possess potent anti-oxidant and anti-inflammatory properties.

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Reliability analysis of shoulder balance measures: comparison of the 4 available methods. At admission the patient exhibited catatonia, a tetraspastic syndrome and focal epileptic seizures.

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Experiments with MOR KO mice and with DAMGO (MOR specific agonist) confirm that the effect of morphine on TLR4 mRNA in peritoneal macrophages is due to the MOR activation. The species of the genus Populus, collectively known as poplars, are widely distributed over the northern hemisphere and well known for their ecological, economical, and evolutionary importance.

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The general practitioner recorded as the preferred primary healthcare provider was contacted and a questionnaire completed. The contrasting data on the toxicity of Ferula communis most probably raised from the use of chemically uncharacterized specimens.

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Informed consent in Italy: a Mediterranean country towards an autonomy-based model. TGXTC-containing sera antagonized SNP-induced CD apoptosis and the molecular basis for the action was associated with up-regulation of Bcl-2, down-regulation of p53 expression, and inhibition of caspase-3 and caspase-9 catalytic activities. Genetic alterations activating K-RAS and PI3K/AKT signaling are also known to induce the activity of mTOR kinase through TORC1 and TORC2 complexes in human pancreatic ductal adenocarcinoma (PDAC). The hypothesis that NGF protection involves changes in antioxidant enzyme expression was tested by measuring its effects on catalase and glutathione peroxidase (GSH Px) mRNA expression in PC12 cells.

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Angiosarcoma of the heart: three-year survival and follow-up by nuclear magnetic resonance imaging. Furthermore, an oscillatory zonal flow is found to form through interaction between the vortex flows and microturbulence. Atopy is the genetic predisposition toward responses that result in the formation of large quantities of allergen-specific IgE. Its stratified epithelia offer protection from environmental stresses such as dehydration, irradiation, mechanical trauma, and pathogenic infection, whereas its appendages, like hair and sebaceous glands, help regulate body temperature as well as influence animal interaction and social behavior through camouflage and sexual signaling. Viral agents in two-stage cervical carcinogenesis: an experimental study in mice.

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A retrospective chart review of 190 consecutive patients with unilateral thyroid nodules undergoing thyroid surgery was undertaken between March 2006 and March 2008. The presented strategy of antibody validation and characterization can be provided a new tool for exploration of human proteome.

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Eighteen 2-tert-butyl-benzazole derivatives were evaluated comparatively as macrofilaricidal agents against L. They provide another dimension by which PGE(2) may inhibit, and perhaps even reverse, fibrogenesis in patients with interstitial lung disease. The van der Waals interactions, especially the important contact with Ile10, dominate in the binding free energy and play a crucial role in distinguishing the different bioactivity of the five inhibitors. After 48 pelviscopic follicle punctures and 39 embryotransfers 12 cases resulted in clinical pregnancies. Construction, screening and identification of a phage display antibody library against the Eimeria acervulina merozoite.

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Suspended cell concentrations were monitored to determine detachment rates, while other variables were measured to determine their influence on the detachment rate. This attitude gives partial support to the present Mental Health Care Act.

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The vestibule has a narrower extension about 10 A long with an average diameter of about 10 A. We have prepared major sperm protein 2 (MSP2) from Onchocerca volvulus as a possible diagnostic antigen for onchocerciasis.

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Although easily examined, abnormalities of the tongue can present a diagnostic and therapeutic dilemma for physicians. These results suggest that NSF is a general component of the transport machinery required for membrane fusion at multiple stages of the secretory pathway.

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All randomised controlled trials of psychological therapies compared to a control, pharmacological therapy or other treatments in children or adolescents exposed to a traumatic event or diagnosed with PTSD. kannadiya kaletra generic name Pairing one compartment with SP (100 pg, 1 ng) significantly increased the time spent in this compartment.

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On the basis of this zival forte music review an expert panel of dermatopathologists and general pathologists discussed and agreed recommendations for general practice. The patient recovered after treatment comprising drainage and intravenous antibiotics. The promise of islet transplantation for type 1 diabetes has been hampered by the lack of a renewable source of insulin-producing cells.

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Preliminary experimental results for optical Gaussian and Laplacian pyramidal image processing are presented. This early skeletal muscle-specific Cre line will be a useful tool to define the function of genes specifically in skeletal muscle. Considerations on domestic violence, gender and the activities of family health teams Oncogeriatrics development for 15 years made it possible to consider two fundamental aspects, which are the geriatric evaluation, from the side effects of rulide roxithromycin dose most simple to the complete one, and the development of specific trials. Two key bitter peptides from Gouda cheese, namely, Tyr-Pro-Phe-Pro-Gly-Pro-Ile-His-Asn-Ser and Leu-Val-Tyr-Pro-Phe-Pro-Gly-Pro-Ile-His-Asn, both activated TAS2R1 and TAS2R39.

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Formaldehyde degradation by photocatalytic Ag-doped TiO2 film of glass fiber roving. Leptin receptor expression at the mRNA level in some individuals ciprager and weight gain may be related to contamination by other cells in semen. Compromised access to prescriptions and medical care because of cost among US adults with arthritis. These observations will aid determination of the status and phenotypic stability of long-term embryonic stem-cell cultures. The functional organization of the internal components of Rice dwarf virus.

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Tenascin was also present in the condensing mesenchyme of developing bones goran pandev vs juventus jersey that form by intramembranous ossification and later was present around the spicules of forming bone. Sustained decrease in fat consumption produced by amphetamine in rats maintained on a dietary self-selection regime. Examination of these strains by conventional microbiologic tests confirmed them to be C.

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Long-term employment of adults with childhood-onset epilepsy: a prospective population-based study. Currently, there is neither a specific treatment nor vaccine available for chikungunya fever. No-needle anesthesia with jet injection is a new technique to deliver rapid onset of profound local anesthesia to the indications and dosage of fluconazole for oral thrush patient undergoing vasectomy.

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Women need advice in regard to disclosure of diagnosis to others and need more information on managing treatment effects. We conducted a prospective study at the Department of Obstetrics and Gynecology, University Hospital of Vienna to investigate associations between serum testosterone levels and maternal peripartal mood states. The use of insect-resistant crops is a very biaxsig 300 mg equals how many grams effective way to control insect pests in agriculture, and the development of such crops can be greatly enhanced by knowledge on plant resistance mechanisms and the genes involved. Gastronet survey on the use of one- or two-person technique for colonoscopy insertion.

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Factors that impede closed reduction in intertrochanteric fractures remain unknown. This study attempts to show, with respect to immunohistochemically stained nuclei, which morphometric parameters may be altered by the different levels of JPEG compression, and fiche pharmacologie augmentin for uti the implications of these alterations for automated nuclear counts, and further, develops a method for correcting this discrepancy in the nuclear count. Between January 1975 and December 1979, 58 patients were diagnosed as having villous papilloma of the large bowel. Further studies on the innate inflammatory response during episodes of acute infection and inflammation are needed to develop targeted therapies to modulate this system, which could, in turn, improve future outcomes and modify the JHR.

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Sudden infant death syndrome: exposure to cigarette smoke leads to hypomethylation upstream of the growth factor independent 1 (GFI1) gene promoter. Cell death is a normal feature within the chick chorioallantoic membrane, occurring principally between days 10 and 14 of incubation. For each subject, the degree to which ribavirin dose reduction anemia signs stroke injured each of 4 descending white matter tracts (from the primary motor cortex, supplementary motor area, dorsal premotor cortex, and ventral premotor cortex, respectively) was determined. It is therefore deterministic and largely avoids the trial and error approach often applied in treatment planning of today. Experimental animal study of spinal cord injury (SCI), using a cell delivery system.

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Social mediation is needed to enhance the QOL of patients with ESRD who lack familial and economic support, those who are single, or those who cannot afford hydroxyzine side effects in canines medical expenses either by themselves or with the help of their parents. Immunological properties of recombinant porin of Haemophilus influenzae type b expressed in Bacillus subtilis.

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Finally, only one of four target characteristics-psychological vulnerability-was significantly associated with violent victimization risk. Pea aphids, Acyrthosiphon pisum, reproduce parthenogenetically and are wing-dimorphic such that offspring can develop into winged (alate) or unwinged (apterous) adults. Therapeutic targeting of the pantoprazole tablets in pregnancy proteins that control apoptosis may therefore be used in the treatment of various types of cancer.