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Topina (Topiramate)
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Topiramate

Topina belongs to a class of drugs called sulfamate-substituted monosaccharide anticonvulsants or antiepileptic drugs (AEDs). A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions. It isn’t known exactly how this drug works. It’s thought that it works on certain chemicals, channels, receptors, and enzymes in your brain to help control seizures and prevent migraines.

Other names for this medication:
Topiramate, Topamax, Epitomax, Letop, Neutop, Piramax, Talopam, Topamac, Topictal, Topigen, Topilex, Topimax, Topina, Topiramato, Topirol, Toplep,

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A key problem in systems biology is estimating dynamical models of gene regulatory networks. This technique was used in eight patients, in all of whom the wounds healed uneventfully. We investigated this with a risk-benefit analysis on a large private wildlife production area in Zimbabwe. Fluorinated tetraolate: prospective ligand for the synthesis of polymetallic complexes.

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We investigated the molecular mechanisms underlying the regulation of the keratin 16 (K16) gene by iAs in the human keratinocyte cell line HaCaT. Arterial pressure and exaggerated natriuresis in spontaneously hypertensive rats. We then discuss the manner in which these behaviors may be functionally interrelated and offer a conceptual framework (S-O-R-C) to guide case conceptualization and treatment planning for clients with co-occurring suicidality and substance use disorders.

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It was a soft tissue mass in the left popliteal area, measuring 14x9 cm. Fifteen microsatellite loci were identified in the tetraploid spined loach, Cobitis biwae (Teleostei: Cobitidae). In acidic, hypoglycemic environment of the splenic pulp the cells become swollen and lysed.

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Extrahepatic portal hypertension is not an uncommon disease in childhood, but isolated inferior mesenteric portal varices and lower gastrointestinal (GI) bleed have not been reported till date. One potential mechanism for the increased risk of hypertension during SLE is the chronic inflammation caused by immune complex mediated tissue injury.

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The results also confirmed that genetic and nutritional factors are strong markers for early menarche. Within the limits of this study, we concluded that the in Brazilian patients studied, the GPF location was more closely related to third molar. In terms of the fully relativistic screened Korringa-Kohn-Rostoker method we investigate the effect of stacking faults on the magnetic properties of hexagonal close-packed (hcp) cobalt. Little is known about their effect on risk perceptions and health behavior. Effects of elevated O3 on the volatile organic compounds emit from Ginkgo biloba and Pinus tabulaeformis

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He made an uneventful recovery and was discharged nine days later. This entails fitting the frequency impulse response, compensating for propagation losses in the amplitude response, and analyzing the phase response. To evaluate the usefulness of blood lactate as an indication for blood transfusion in anaemia of prematurity by means of a study protocol which considers the site of blood sampling and the repeatability of lactate measurements. Self-reported peer victimization and child mental health: results of a cross-sectional survey among French primary school children. Comparison of Bayesian network and decision tree methods for predicting access to the renal transplant waiting list.

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Furthermore, medication used in this study showed good tolerability. In 2008, the NTCS enrolled its first cohort of students in a new hybrid CBME program based in urban Darwin. Forty eight patients with cirrhosis without overt hepatic encephalopathy (17 Child A, 13 Child B, and 18 Child C) and 51 healthy subjects were matched for age and sex.

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None of the amyloids stained with anti-sera to prealbumin, to serum amyloid A protein, or to the free kappa or lambda light chains of immunoglobulins. Conceptal P450IA1 catalyzed the conversion of dysmorphogenically inactive 2-acetylaminofluorene to 7-hydroxy-2-acetylaminofluorene, a proximate dysmorphogen.

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To examine the effect of a 12-month aerobic exercise intervention on CRP levels in men and women. Induction of cell cycle arrest and apoptosis by 5-fluorouracil in laryngeal cancer cells containing HPV16 E6 and E7 oncoproteins. Endoscopic polypectomy of the large bowel: management of cancer-bearing polyps. This evidence summary is based on a systematic search and review of the literature published between 1985 and February 2004. Through minor adjustment of the rotamers of two amino acid side chains for this latter structure, a model that not only provided a lower energy conformation but also completely satisfied previously reported data from NMR and tryptophan fluorescence measurements, in addition to the solvent-accessibility data presented here, was generated.

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Such treatment did not affect aggregation but in most experiments enhanced proliferation. The magnitude and duration of the depression of SMA after injury correlated both with the ISS and with the probability of mortality.

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30 virus specific proteins was tested in an enzyme linked immunoassay (ELISA) whereas their ability to detect RCMV-antigens at different locations of in vitro infected cell cultures and at different stages of infection was tested by immunofluorescence. The effectiveness of knowledge-based word sense disambiguation (WSD) approaches depends in part on the information available in the reference knowledge resource.

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Accumulations of nonfibrillar perivascular IAPP-immunoreactive material were found between capillaries and beta-cells in hIAPP transgenic mice but not in rIAPP transgenic or control mice. Prevention of cancer and inflammation by soybean protease inhibitors. Areas of destroyed squamous epithelium are then progressively reepithelized by a columnar epithelium that may originate from multipotent stem cells located within the basal layer of the normal esophageal mucosa or in the ducts of submucosal glands. It is characterized by excessively increased levels of the phosphaturic hormone fibroblast growth factor 23 (FGF23) and a deficiency of its co-receptor Klotho.

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The 5-HT3 agonist and antagonists showed little or no effect following injection into the median raphe nucleus and there were no changes in exploratory behaviour following their injection, or injection of diazepam, into the nucleus accumbens or caudate-putamen. The possibility to use the system in automated DNA sequencing is discussed. The present study showed that 17beta-estradiol of steroid hormones, which are well known to have various effects on hippocampal neurons, has a significant influence on the presynaptic expression of CD18 in synaptogenesis and inhibited synaptogenesis in the early developmental stage in vitro. Postoperative course was uneventful, and the patient was doing well one year after the operation without neurological dysfunction.

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Nitric oxide (NO), a key macrophage antimycobacterial mediator that ameliorates immunopathology, is measurable in exhaled breath in individuals with pulmonary tuberculosis. There is a growing body of evidence to show that AGEs-their receptor (RAGE) interactions are involved in the development of atherosclerosis and diabetic microangiopathy.

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Clinical findings other than respiratory distress included hepatomegaly, ventral edema, orthopnea, and a jugular pulse. Fatal bacteremia caused by Campylobacter gracilis, United States. Amino acid position 305 was critical to epitope I, whereas amino acid position 433 was critical to epitope III. These results raise the possibility that fibronectin may be involved in attaching asymmetric AcChE to cell surfaces.

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A three-step PCR screening method was used to identify PLE-positive clones by screening a Rongchang pig BAC library and PacBio third-generation sequencing was performed. Beta-thalassemia major complicated with Vibrio vulnificus septicemia: report of one case

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CIN85 and Cbl are involved in endocytosis and negative regulation of numerous receptor tyrosine kinases. Altered mRNA expressions of sialyltransferases in human gastric cancer tissues.

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The time-resolved x-ray diffraction and optical results show that the dynamics span from subpicosecond local photoswitching followed by volume expansion (nanosecond) and thermal switching (microsecond). tuberculosis isolates needs prioritization to ensure success in national tuberculosis control programme. This study emphasised the importance of a statewide review of the specificity and sensitivity of the anatomical fetal ultrasound examination, in view of the expansion of this procedure and its variable quality depending on operator experience and equipment quality. A history of heavy smoking at the time of initial resection may be a risk factor. Additional effort is necessary to customize URWs when utilized for activities beyond their original purpose of community mobilization.

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Design aspects of compliant, soft layer bearings for an experimental hip prosthesis. Though equally relevant to a scientific inquiry into art appreciation, psychological and historical approaches to art developed independently and lack a common core of theoretical principles. This article introduces an efficient technique for the calculation of vapor-liquid equilibria of fluids.

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Transmural activations and stimulus potentials in three-dimensional anisotropic canine myocardium. It is stated that diabetic syndrome in males proceeds in more serious form than in females.

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Two sets of features were calculated from MRI recordings: dynamic parameters reflecting diaphragm action, and static parameters reflecting diaphragm anatomic characteristics. These calculations cannot say with certainty which functional should be favoured, nor the preferred spin state of the catalytically active species. Binding of C-reactive protein (CRP) by human peripheral blood lymphocytes in vivo. All Arcobacter isolates typed in this study contain two glyA genes, one linked to lysS (glyA1) and the other linked to ada (glyA2).

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The disialoganglioside fraction contained GD3 as the major component plus GD1a, GD2 and GD1b. The results obtained together with previous high-resolution structural data on the phi6 RNA-dependent RNA polymerase suggest a mechanism for terminal nucleotidyl addition. Emphysematous vaginitis masquerading as carcinoma of the cervix.

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Evidence for only two independent pathways for decreasing senescence in Caenorhabditis elegans. Seizure duration of less than 6 months was associated with very active grades, duration of 1-2 years with variable grades, and duration greater than 6 years with chronic and resolving grades only. Survivors of childhood acute lymphoblastic leukemia (ALL) exhibit increased rates of neurocognitive deficits. Numerous targets are being explored using multiple approaches for their involvement in the self-renewal or survival as well as radioresistance of breast TICs. This study uses DTI techniques to quantify structural integrity change to determine whether regional differences are apparent in the rate of degeneration during longitudinal follow-up in a sample of healthy middle aged and older adults aged between 50 and 90years.

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It comprises basic analysis steps as lollipop visualization, co-occurrence display of methylation of neighbouring and distant CpG sites, summary statistics on methylation status, clustering and correspondence analysis. Osteoid osteoma can be distinguished from compact osteoma by the presence in its centre of a cavity (nidus) which is distinctly visible on tomography or CT scans. The deployment of new antimalarials in Africa provides an important opportunity to develop systems for pharmacovigilance. The clinical dynamics and effect of electrophoresis of mexidol and dimephosphon as a monotherapy as well as in combination with variable magnetic field and darsonvalization on mechanisms of electrophysiological processes, ways of formation of cerebral hemodynamic effects and adaptation in the functional systems of homeostasis and microcirculation and on the pathophysiological cascade of brain metabolism in single/serial applications were studied. Misoprostol given as once-daily suppository for prevention of acute radiation-induced proctitis does neither influence the incidence and severity of radiation-induced acute nor late rectal toxicity.

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The muscles, fin ray joints, and supporting structures underlying the dorsal fin are described for two seahorse species: Hippocampus zosterae and Hippocampus erectus. Therefore, the differentiated and selective pharmacologic modulation of NO-mediated vascular function could play a useful role in hemodynamic management of patients with sepsis. HIF-1alpha might confer to resistance of cell apoptosis induced by Taxol. P42 MAPK (ERK2) activity and XRINGO accumulation are also required for the activating phosphorylation of CPEB. Radial immunodiffusion assays of hepatic supernatant using a polyclonal antibody raised against PK1B-reactive bile acid sulfotransferase show that changes in specific activity that follow treatment are the result of changes in enzyme protein concentration.

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A study was conducted to evaluate sensitivities of WNV screening and supplemental NAT assays first employed in 2003. The use of the insect cell/baculovirus expression system for producing recombinant proteins of bacterial, plant, insect, and mammalian origin has become widespread. Within 10 m of the oil well, sulfate concentrations were low, and sulfate was enriched in both 34S and 18O.

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A lipase-encoding gene was isolated from a genomic library of the insect pathogen Serratia proteamaculans 8805412. Dental and radiographic findings as predictors of osteoporosis in postmenopausal women. TPO genetic variants and risk of differentiated thyroid carcinoma in two European populations.

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cerevisiae counterparts and in some ways are more similar to metazoan complexes. Interventions to promote return to work (RTW) after sickness absence are often complex, involving numerous stakeholders and thus prone to implementation problems. The activity of these identified neurons was tested for a response to activation of peripheral baroreceptors, achieved by rising arterial blood pressure with an intravenous administration of the alpha-agonist metaraminol. Investigation of the influence of spatial coherence of a broad-area laser diode on the interference fringe system of a Mach-Zehnder interferometer for highly spatially resolved velocity measurements.

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Hydrogen and carbon dioxide were used as energy and carbon source. Experimental and clinical studies and topical reviews on the electrophysiologic mechanisms and treatment of torsade de pointes were analyzed. These lectins include the serum proteins conglutinin, mannose-binding lectin (MBL) and Collectin-43 (CL-43) and the lung surfactant proteins A and D (SP-A and SP-D). Endothelial function in women with singleton pregnancies between 16 and 23 weeks was analyzed utilizing the Endo-PAT2000 device (Itamar Medical Ltd., Caesarea, Israel) and expressed as a reactive hyperemia ratio (RHI). This paper presents some examples of significant efforts in western medical education on the Chinese mainland during the 19th century.

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The atrial wall was partially resected and anastomosed to the pericardial wall around the incised PV. Hornerin mRNA was detected in the UVB-irradiated skin on day 2 using RT-PCR. This allows upregulation of antimicrobial peptides, such as gloverin, that are controlled by the Toll pathway and activation of proteolytic cascades essential for humoral immune responses to foreign invasion. In women with PMS the Authors did not point out important psychopathological aspects, therefore the PMS is not evidence for psychiatric illness. The classifier relies on a multilayer neural network based on a back propagation algorithm with one hidden layer of four neurons and eight neurons at the input and five neurons at the output.

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This article reviews the relevant embryology of the inguinal canal, discusses abdominal and scrotal conditions that involve the inguinal region, and illustrates associated pathology. Role of home monitoring in children with implantable cardioverter defibrillators for Brugada syndrome. Exposure to low-dose trichloroethylene alters shear stress gene expression and function in the developing chick heart. Xylan as limiting factor in enzymatic hydrolysis of nanocellulose. They were then randomly assigned 12 each to audiofeedback, visual feedback, audiovisual feedback, and no feedback groups.

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Thus, many novel separation techniques with significant advantages over conventional methods were introduced and applied to separation and analysis of the chemical constituents in TCM. This was a descriptive study that included all singleton pregnant women who had a second trimester amniocentesis for chromosome studies at the Maternal Fetal Medicine Unit, Department of Obstetrics and Gynecology, Songklanagarind Hospital between January 1998 and 2006 to assess the outcome including risk of fetal loss in such cases.

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In the presence of ET-1 (0.1 nM or higher concentration), the rate of ouabain-sensitive potassium (86Rb) uptake was diminished. Description of four novel species of Xenorhabdus, family Enterobacteriaceae: Xenorhabdus budapestensis sp. High-throughput genotyping approaches are being developed to meet the demands of pharmacogenomnics, where numerous individuals are studied with thousands of single nucleotide polymorphism (SNP) markers. By detergent-free purification of lipid raft-rich membrane fractions and fluorescence immunocytochemistry, we found that mechanical stretch translocates caveolin-1 from the plasma membrane to the cytoplasm. Children performed a pictorial dot-probe task before and after stepped-care CBT (i.e., before phase one and after phase two CBT).

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Shock due to Gram-negative bacterial sepsis is a consequence of acute inflammatory response to lipopolysaccharide (LPS) or endotoxin released from bacteria. A revised model of decisional balance demonstrated sufficient evidence for ME/I between genders and among ethnicities, but not among age groups. Sol-gel low-temperature synthesis of stable anatase-type TiO2 nanoparticles under different conditions and its photocatalytic activity.

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Hence, the EBF focuses their recommendation on introducing terminology around scientific qualification or validation to be used in relation to AMS. Measurement of the setting and thermal expansion of dental investments used for the superplastic forming of dental implant superstructures. NIH3T3-fibroblasts producing endogenous BDNF were incorporated in UHV-alginate. Sequences with high identity to these genes have been found in the genome of clinical and environmental strains, suggesting that the Pi-starvation response in V. Along with parallel-receive, ECG-gating and multiplexed imaging, these new techniques were used to form high-quality, high-resolution epicardial ARFI images.

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Species identification of Ixodes granulatus (Acari: Ixodidae) based on internal transcribed spacer 2 (ITS2) sequences. AFLPs do not support deep phylogenetic relationships among darters (Teleostei: Percidae: Etheostomatinae). During physical examination, there was no abnormality in either hairs or nails, perspiration was normal and no congenital clefts of lip or palate was seen.

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Distribution and time-course of DiR-lipidots are followed using in vivo fluorescence reflectance imaging and reveal enhanced fluorescent signal within the subcutaneous tumors up to seven days due to the enhanced permeability and retention effect. This is an area in which more data are required for rational design of improved linkers. A diagnosis of left carotid sinus hypersensitivity of the vasodepressor variety was made.

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The coronary artery disease (CAD) patients are not free of disease recurrence following coronary artery bypass graft (CABG) surgery. The dependence group duovir efavirenz and depression were more likely to experience higher estimates of social problems compared to one-criterion orphans. In this work, the effect of the degree of smaller scale surface roughness on the hysteresis width has been studied using mean-field density functional simulations and the results obtained confirmed by experiments on silica materials.

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How nanoparticles interact with biomembranes is central for understanding their bioactivity. These data provide new insights into the determinants of BH3 domain:pro-survival protein affinity and selectivity. Physiological changes that amoxydar forte 500 dosage index occur during exposure to weightlessness may induce alterations in blood flow to the liver. The nitroreductase and acetyltransferase genes of Salmonella typhimurium TA1538 have been cloned into pBR322.

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